
Federally funded research and development centers (FFRDCs) are public-private partnerships which conduct research for the United States Government. They are administered in accordance with U.S. Code of Federal Regulations, Title 48, Part 35, Section 35.017 by universities and corporations. There are currently 42 recognized FFRDCs that are sponsored by the U.S. government. FFRDCs are similar to the University Affiliated Research Centers run by the United States Department of Defense.

Argonne National Laboratory is a science and engineering research national laboratory operated by UChicago Argonne LLC for the United States Department of Energy. The facility is located in Lemont, Illinois, outside of Chicago, and is the largest national laboratory by size and scope in the Midwest.

Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, New York, on Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base. Its name stems from its location within the Town of Brookhaven, approximately 60 miles east of New York City. It is managed by Stony Brook University and Battelle Memorial Institute.

CNA, formerly known as the CNA Corporation, is a nonprofit research and analysis organization based in Arlington County, Virginia. CNA has around 625 employees.

Fermi National Accelerator Laboratory (Fermilab), located just outside Batavia, Illinois, near Chicago, is a United States Department of Energy national laboratory specializing in high-energy particle physics. Since 2007, Fermilab has been operated by the Fermi Research Alliance, a joint venture of the University of Chicago, and the Universities Research Association (URA). Fermilab is a part of the Illinois Technology and Research Corridor.

The Frederick National Laboratory for Cancer Research (FNLCR) is a United States federally funded research and development center (FFRDC) supported by the National Cancer Institute and managed by the private contractor Leidos Biomedical Research. The institution was originally established under the name Frederick Cancer Research and Development Center in 1972 as a component of President Richard Nixon's War on Cancer initiative. In 2012, the institution received a national laboratory designation and assumed its current name, becoming the only U.S. national laboratory exclusively dedicated to biomedical research. The campus in Frederick, Maryland also houses National Cancer Institute laboratories and administrative organizations, and is colloquially referred to as NCI-Frederick.

Idaho National Laboratory (INL) is one of the national laboratories of the United States Department of Energy and is managed by the Battelle Energy Alliance. While the laboratory does other research, historically it has been involved with nuclear research.

The Jet Propulsion Laboratory (JPL) is a federally funded research and development center and NASA field center in the city of La Cañada Flintridge, with a Pasadena mailing address, in California, United States.

The Lawrence Berkeley National Laboratory (LBNL), commonly referred to as Berkeley Lab, is a United States national laboratory that conducts scientific research on behalf of the Department of Energy. Located in the hills of Berkeley, California, the lab overlooks the campus of the University of California, Berkeley.

Lawrence Livermore National Laboratory (LLNL) is a federal research facility in Livermore, California, United States, founded by the University of California, Berkeley in 1952. Originally a branch of the Lawrence Berkeley National Laboratory, the Lawrence Livermore laboratory became autonomous in 1971 and was designated a national laboratory in 1981.

Los Alamos National Laboratory is a United States Department of Energy national laboratory initially organized during World War II for the design of nuclear weapons as part of the Manhattan Project. It is located a short distance northwest of Santa Fe, New Mexico, in the southwestern United States.

The Mitre Corporation is an American not-for-profit organization based in Bedford, Massachusetts, and McLean, Virginia. It manages federally funded research and development centers (FFRDCs) supporting several U.S. government agencies.

The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship.

The US National Center for Atmospheric Research is a US federally funded research and development center (FFRDC) managed by the nonprofit University Corporation for Atmospheric Research (UCAR) and funded by the National Science Foundation (NSF). NCAR has multiple facilities, including the I. M. Pei-designed Mesa Laboratory headquarters in Boulder, Colorado. Studies include meteorology, climate science, atmospheric chemistry, solar-terrestrial interactions, environmental and societal impacts.

The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland. The NIH conducts its own scientific research through its Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program.

Oak Ridge National Laboratory is an American multiprogram science and technology national laboratory sponsored by the U.S. Department of Energy (DOE) and administered, managed, and operated by UT–Battelle as a federally funded research and development center (FFRDC) under a contract with the DOE. Established in 1942, ORNL is the largest science and energy national laboratory in the Department of Energy system and third largest by annual budget. ORNL is located in the Roane County section of the city of Oak Ridge, Tennessee. ORNL's scientific programs focus on materials, neutron science, energy, high-performance computing, systems biology and national security.

RAND Corporation is an American nonprofit global policy think tank created in 1948 by Douglas Aircraft Company to offer research and analysis to the United States Armed Forces. It is financed by the U.S. government and private endowment, corporations, universities and private individuals. The company has grown to assist other governments, international organizations, private companies and foundations, with a host of defense and non-defense issues, including healthcare. RAND aims for interdisciplinary and quantitative problem solving by translating theoretical concepts from formal economics and the physical sciences into novel applications in other areas, using applied science and operations research.

The UNC Lineberger Comprehensive Cancer Center is a cancer research and treatment center at the University of North Carolina at Chapel Hill. One of 71 National Cancer Institute-designated comprehensive cancer centers in the United States, its clinical base is the N.C. Cancer Hospital, part of the UNC Health Care system. UNC Lineberger is the only public NCI-designated comprehensive cancer center in the state of North Carolina. The current director is H. Shelton Earp III who succeeded current NCI director Norman Sharpless