
Colobot is an educational real-time strategy video game featuring 3D graphics, created by Swiss developer Epsitec SA. The objective of the game is to find a planet for colonization by the human race by establishing a basic infrastructure on the surface and eliminating any alien life forms endangering the expedition. The game takes place on the Earth, Moon, and seven fictional planets. The main feature of the game, which makes it educational, is the possibility for players to program their robots using a programming language similar to C++ or Java.

Decodoku is set of online citizen science games, based on quantum error correction. The project is supported by the NCCR QSIT and the University of Basel, and allows the public to get involved with quantum error correction research.

Empyrion - Galactic Survival is an open-world sandbox adventure game. It was released via early access on 5 August 2015 by Eleon Game Studios.

FAR: Lone Sails is an exploration adventure video game developed by the Swiss development company Okomotive. The game released on Microsoft Windows and macOS on 17 May 2018, with Xbox One and PlayStation 4 versions released in April 2019, and the Nintendo Switch version on 18 August 2019. It was released in Japan on January 23, 2020.

Farming Simulator is a farming simulation video game series developed by Giants Software and published by Focus Home Interactive. The locations are based on American and European environments. Players are able to farm, breed livestock, grow crops and sell assets created from farming.

GATE is an action-adventure video game designed by Swiss programmers Henrik Gudat, Jörg Kienzle, and Yann Le Tensorer. The gameplay is comparable to Nintendo's The Legend of Zelda with a top-down view and a mixture of action, adventure, and puzzle solving.

GLtron is a 3D snake game based on the light cycle portion of the film Tron. The game is free and open-source software and has been ported to many mobile and non-mobile operating systems such as Windows, MacOS, Symbian and Android over the years.

Insanity Fight is a vertically scrolling shooter developed by Linel for the Amiga and originally published by Microdeal in 1987. An iOS port from the original programmer was released in 2014.

LP Recharge, also known as Linkin Park Recharge, is a free-to-play action-puzzle game, developed by Swiss studio Kuuluu Interactive Entertainment, which is composed by American rock band Linkin Park. The game was released on September 12, 2013, as it is a current playable game on Facebook. The game is focused on solving puzzles and also attempting to raise awareness about parts of the world that don’t have reliable power.

Plobb! is a single-player 2D freeware game developed with BlitzMax. The game involves the player guiding the small blob-shaped main character named "Plobb" around the screen where he is attacked by enemy bubbles. The aim is to eliminate the bubbles and finally also the arch-enemy in order to win the game and regain Plobb's freedom.

Speedy Eggbert, originally Speedy Blupi, is a video game for Windows based PCs developed by EPSITEC, and released on September 13, 1998 as an independent title. It is part of the Blupi series, and the successor to Planet Blupi.

Train Fever is a business simulation game by Urban Games, funded via the crowdfunding platform Gambitious on 20 March 2012 for a total budget of €300,000 and therefore published digitally by Gambitious Digital Entertainment and to retail by Astragon.

Transport Fever is a business simulation game developed by Urban Games and published by Gambitious Digital Entertainment. It is the second video game of the Transport Fever franchise, and was available worldwide for Microsoft Windows and macOS on 8 November 2016.

Transport Fever 2 is a business simulation game developed by Urban Games and published by Good Shepherd Entertainment. It is the third video game of the Transport Fever franchise, and became available for Microsoft Windows and Linux on 11 December 2019.

Traps 'n' Treasures is a platforming and action-adventure video game developed by Roman Werner for the Amiga. Initially released in Germany in 1993 by Starbyte Software, the English version of the game was released several months later, in 1994, by Krisalis Software.