
Call of Cthulhu is a horror fiction role-playing game based on H. P. Lovecraft's story of the same name and the associated Cthulhu Mythos. The game, often abbreviated as CoC, is published by Chaosium; it was first released in 1981 and is in its seventh edition, with licensed foreign language editions available as well. Its game system is based on Chaosium's Basic Role-Playing (BRP) with additions for the horror genre. These include special rules for sanity and luck.

Cubicle 7 Entertainment Ltd is an Irish games company that creates and publishes tabletop games. Best known for its Doctor Who and Lord of the Rings games, Cubicle 7 offers titles covering a range of licensed and self-developed properties.

CthulhuTech is a science-fiction and horror roleplaying game created by Wildfire LLC and published by Sandstorm that combines elements of the Cthulhu Mythos with anime-style mecha, horror, magic and futuristic action. The setting is Earth in 2085 during a worldwide conflict known as the Aeon War, wherein the planet has been invaded twice: once by a black-skinned manufactured alien race known as the Nazzadi who are derived from humans and who join forces with them, and then a second time by the Mi-Go, an advanced alien civilization seemingly bent on the enslavement of humanity. Aside from these conflicts, the game focuses on other factions, such as ancient cults like the Esoteric Order of Dagon that are running amok across the planet and the eldritch horrors that are rising to destroy the world as, according to the prophecies of the Cthulhu Mythos, the "stars are right" and the Great Old Ones and their servitors are returning/reawakening to reclaim the Earth. The game uses a proprietary ten-sided die (d10) system titled "Framewerk."

Delta Green is a setting for the Call of Cthulhu role-playing game created by Adam Scott Glancy, Dennis Detwiller, and John Scott Tynes, a.k.a. the Delta Green Partnership, of the Seattle gaming house Pagan Publishing. Delta Green is set in the contemporary era and revolves around a highly secretive organization known as Delta Green, tasked with protecting the United States from paranormal and alien threats. Delta Green takes the classic setting of the Cthulhu Mythos from Call of Cthulhu and mashes it with conspiracy fiction.

The Laundry is a tabletop role-playing game published by Cubicle 7 in 2010. The game is based on novelist Charles Stross's the Laundry Files series.

Spaceship Zero is the title of a media franchise that includes a role-playing game and an indie rock CD.

Trail of Cthulhu is an investigative horror role-playing game published by Pelgrane Press in which the players' characters investigate mysterious events related to the Cthulhu Mythos. It was designed by Kenneth Hite using the Gumshoe System, which was created by Robin Laws. Trail of Cthulhu is based on the Call of Cthulhu role playing game under license from Chaosium.