
Aveline de Grandpré is a fictional character in Ubisoft's Assassin's Creed video game franchise. She first appears as the protagonist of Assassin's Creed III: Liberation, originally released for PlayStation Vita in October 2012, and also appears in Assassin's Creed IV: Black Flag. She is voiced by Amber Goldfarb.

Corvo Attano is a fictional character of Arkane Studios' Dishonored universe. He is the lead protagonist in Dishonored, one of two playable protagonists in Dishonored 2, and has appeared in multiple Dishonored fictional works, including a comic series, and the first published book of a trilogy of novels announced in 2016.

Edward James Kenway is a fictional character in Ubisoft's Assassin's Creed video game franchise. He first appears in Assassin's Creed: Forsaken, a companion novel to the 2012 video game Assassin's Creed III, as a supporting character. He is the primary protagonist of the 2013 video game Assassin's Creed IV: Black Flag, and its novelization Assassin's Creed: Black Flag. The character's other appearances include the spin-off mobile game Assassin's Creed: Rebellion.

Emily Kaldwin is a fictional character of the Dishonored series. She is a lead protagonist in the sequel, Dishonored 2. In the story of the first game, she is the daughter of the Empress and the player-character, Corvo. When the Empress is assassinated and Emily kidnapped, the player recovers Emily whereupon she serves as a moral compass by expressing herself differently based on the player's proclivity for violence in their gameplay choices. Emily reigns for 15 years leading up to the sequel's story, when she is usurped and escapes to plot her revenge. The developers noted Emily and her relationship with the player as one of the most compelling elements they took to the sequel. Her announcement as its protagonist was unveiled as a surprise and welcomed by games journalists as emblematic of progress for female representation in video games, leading an industry trend towards more prevalent lead female protagonists at the 2015 Electronic Entertainment Expo.

Isabelle, known as Shizue (しずえ) in Japan, is a fictional character from the Animal Crossing series of video games. She is a kindly Shih Tzu that debuted in the 2012 release Animal Crossing: New Leaf, where she serves as the secretary to the player character. Isabelle has received positive reception, to the point of becoming one of the most prominent characters in the Animal Crossing franchise and its de facto mascot. Her popularity has also led to appearances outside of the Animal Crossing series, including a playable role in the crossover fighting game Super Smash Bros. Ultimate.

Kat, known in Japan as Kitten, is a fictional character and the protagonist of the Gravity Rush series. A young woman with retrograde amnesia, she awakens in the city of Hekseville after falling from the sky, and sets out to discover the origins of her power to shift gravity. She becomes a hero to the people of the city after defending them from the threat of mysterious creatures called the Nevi. Her powers stem entirely from Dusty, a supernatural, cat-like organism that is bound to her, and whom she later realizes is a type of being known as a Guardian. Kat has received critical praise for the unique nature of her powers, leading to inventive gameplay scenarios, as well as her optimistic personality, which has been noted to set her apart from typical superheroes.

Lee Everett is the playable protagonist in the first season of The Walking Dead video game series. Tasked with protecting a girl named Clementine in the midst of a zombie apocalypse, Lee allies with several other characters and groups. When creating Lee, the developers attempted to achieve realism, with a strong emphasis on him being a parental figure to Clementine. He is voiced by Dave Fennoy, an American voice actor. He received positive reception for his role in the game, specifically the voice work and the writing. Fennoy was nominated for Best Performance by a Human Male at the Spike VGA.

Lucina is a fictional character and one of the protagonists from Intelligent Systems's 2012 role-playing video game Fire Emblem Awakening, part of their overarching Fire Emblem series of video games. Her popularity later led to her inclusion in several other video games, including Intelligent System's 2015 title Code Name: S.T.E.A.M., Nintendo's crossover fighting game Super Smash Bros. for Nintendo 3DS and Wii U and its sequel Super Smash Bros. Ultimate, Capcom's Monster Hunter Frontier G, and Bandai Namco's crossover RPG Project X Zone 2. Lucina would again appear in future Fire Emblem titles as well, including Fire Emblem Fates, Fire Emblem Heroes, and Fire Emblem Warriors, though in more of a supporting role rather than a protagonist with the latter titles.

The Outsider is a fictional supernatural being in Arkane Studios' Dishonored franchise, residing in an empty otherworldly dimension called the Void. After appearing in promotional webisodes, the character made his game debut in Dishonored (2012), where he grants magical powers to the player character. He serves a similar role in the game's sequel, Dishonored 2 (2016), though he may be rejected. The Outsider reappears in Dishonored: Death of the Outsider (2017), which follows former-assassin Billie Lurk as she attempts to kill or otherwise neutralize him. Within the series' fiction, the Outsider is one of many representations of the Void that have existed, and was originally a street urchin before being sacrificed by a cult. Voiced by Billy Lush in the first game, the actor was replaced by Robin Lord Taylor for Dishonored 2 onwards.