
Americans for Medical Progress (AMP) is a charity that aims to protect and advocate for society's investment in medical research. As a specific goal, AMP states that it promotes "public understanding of and support for the appropriate role of animals in biomedical research so that scientists are able to continue their quest for cures and improved methods of treatment for illness, injury and disease." Although in favor of moderate animal welfare measures, the AMP is often sharply critical of more radical animal rights groups such as PETA and the similarly named Americans For Medical Advancement.

Roger S. Fouts is a retired American primate researcher. He was co-founder and co-director of the Chimpanzee and Human Communication Institute (CHCI) in Washington, and a professor of psychology at the Central Washington University. He is best known for his role in teaching Washoe the chimpanzee to communicate using a set of signs taken from American sign language.

Gordo was one of the first monkeys to travel into space. As part of the NASA space program, Gordo, also known as Old Reliable, was launched from Cape Canaveral on December 13, 1958, in the U.S. PGM-19 Jupiter rocket on its AM-13 mission. The rocket would travel over 1,500 miles and reach a height of 310 miles (500 km) before returning to Earth and landing in the South Atlantic. A technical malfunction prevented the capsule's parachute from opening and, despite a short search, neither his body nor the vessel were ever recovered.

Harry Frederick Harlow was an American psychologist best known for his maternal-separation, dependency needs, and social isolation experiments on rhesus monkeys, which manifested the importance of caregiving and companionship to social and cognitive development. He conducted most of his research at the University of Wisconsin–Madison, where humanistic psychologist Abraham Maslow worked with him for a short period of time.

The National Association for Biomedical Research (NABR) is an American non profit organization, 501(c)(6), located in Washington, DC. NABR was formed in 1985 when the Association of Biomedical Research merged with the National Society for Medical Research The NABR advocates for the continued use of animals in biomedical research albeit in as humane a manner as possible.

The Oregon National Primate Research Center (ONPRC) is one of seven federally funded National Primate Research Centers in the United States and has been affiliated with Oregon Health and Science University (OHSU) since 1998. The center is located on 200 acres (0.81 km2) of land in Hillsboro, Oregon. Originally known as the Oregon Regional Primate Research Center (ORPRC), it was the first of the original seven primate centers established by the National Institutes of Health (NIH). The research center is administered and funded by the National Center for Research Resources, receiving $11 million in federal grants annually.

The Pit of despair was a name used by American comparative psychologist Harry Harlow for a device he designed, technically called a vertical chamber apparatus, that he used in experiments on rhesus macaque monkeys at the University of Wisconsin–Madison in the 1970s. The aim of the research was to produce an animal model of depression. Researcher Stephen Suomi described the device as "little more than a stainless-steel trough with sides that sloped to a rounded bottom": A 3⁄8 in. wire mesh floor 1 in. above the bottom of the chamber allowed waste material to drop through the drain and out of holes drilled in the stainless-steel. The chamber was equipped with a food box and a water-bottle holder, and was covered with a pyramid top [removed in the accompanying photograph], designed to discourage incarcerated subjects from hanging from the upper part of the chamber.

The Silver Spring monkeys were 17 wild-born macaque monkeys from the Philippines who were kept in the Institute for Behavioral Research in Silver Spring, Maryland. From 1981 until 1991, they became what one writer called the most famous lab animals in history, as a result of a battle between animal researchers, animal advocates, politicians, and the courts over whether to use them in research or release them to a sanctuary. Within the scientific community, the monkeys became known for their use in experiments into neuroplasticity—the ability of the adult primate brain to reorganize itself.

The Roman L. Hruska U.S. Meat Animal Research Center (USMARC) is a livestock research facility in Clay Center, Nebraska. The center researches methods for increasing the efficiency of livestock production. The center maintains around 30,000 animals for its experiments, 44 scientists, and 73 technicians. It is also used as a classroom for teaching animal care.

In 1985, a raid took place at a laboratory belonging to the University of California, Riverside (UCR) that resulted in the removal of a monkey by the Animal Liberation Front (ALF). This monkey, called Britches, was a stump-tailed macaque who was born into a breeding colony at UCR. He was removed from his mother at birth, had his eyelids sewn shut, and had an electronic sonar device attached to his head—a Trisensor Aid, an experimental version of a blind travel aid, the Sonicguide—as part of a three-year sensory-deprivation study involving 24 infant monkeys. The experiments were designed to study the behavioral and neural development of monkeys reared with a sensory substitution device.

The University of Minnesota runs a number of studies involving non-human primates, most notably research into drug addiction. The studies have attracted the attention of local and national animal rights groups, most especially the drug addiction studies of Marilyn Carroll, which she performs on primates, rats, and mice.

Unnecessary Fuss is a film produced by People for the Ethical Treatment of Animals (PETA), showing footage shot inside the University of Pennsylvania's Head Injury Clinic in Philadelphia. The raw footage was recorded by the laboratory researchers as they inflicted brain damage to baboons using a hydraulic device. The experiments were conducted as part of a research project into head injuries such as is caused in vehicle accidents.

Jerry Vlasak is an American animal rights activist and former trauma surgeon. He is a press officer for the North American Animal Liberation Press Office, a former director of the Animal Defense League of Los Angeles, and an advisor to SPEAK, the Voice for the Animals.