
Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. Recently, a hypothesis suggested that it may have a potential role in treatment of Paget's disease of bone, Parkinsonism, and other common diseases of aging-associated diseases involving dysfunction of autophagy. Ambroxol is often administered as an active ingredient in cough syrup.

Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus.

Carbocisteine, also called carbocysteine, is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Carbocisteine should not be used with antitussives or medicines that dry up bronchial secretions.

Creosote is a category of carbonaceous chemicals formed by the distillation of various tars and pyrolysis of plant-derived material, such as wood or fossil fuel. They are typically used as preservatives or antiseptics.

Guaiacolsulfonate is an aromatic sulfonic acid used in medicine as an expectorant.

Guaifenesin, sold under the brand name Mucinex among others, is a medication used to try to help cough out phlegm from the airways. It is unclear if it decreases coughing. Use is not recommended in children less than 6 years old. It is often used in combination with other medications. It is taken by mouth.

Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder. It is used either by mouth or injection into a vein.

Pentethylcyclanone is an antitussive medication.

Potassium iodide is a chemical compound, medication, and dietary supplement. As a medication it is used to treat hyperthyroidism, in radiation emergencies, and to protect the thyroid gland when certain types of radiopharmaceuticals are used. In the developing world it is also used to treat skin sporotrichosis and phycomycosis. As a supplement it is used in those who have low intake of iodine in the diet. It is given by mouth.

Sobrerol is a mucolytic.

Stepronin is a mucolytic and expectorant.

Tipepidine (INN), also known as tipepidine hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen.