
Sloths are a group of arboreal Neotropical xenathran mammals, constituting the suborder Folivora. Noted for their slowness of movement, they spend most of their lives hanging upside down in the trees of the tropical rainforests of South America and Central America. They are considered to be most closely related to anteaters, together making up the xenarthran order Pilosa. There are six extant sloth species in two genera – Bradypus and Choloepus. Despite this traditional naming, all sloths actually have three toes on each rear limb, although two-toed sloths have only two digits on each forelimb. The two groups of sloths are from different, distantly related families, and are thought to have evolved their morphology via parallel evolution from terrestrial ancestors. Besides the extant species, many species of ground sloths ranging up to the size of elephants inhabited both North and South America during the Pleistocene Epoch. However, they became extinct during the Quaternary extinction event around 12,000 years ago, together with most large bodied animals in the New World. The extinction correlates in time with the arrival of humans, but climate change has also been suggested to have contributed. Members of an endemic radiation of Caribbean sloths formerly lived in the Greater Antilles. They included both ground and arboreal forms which became extinct after humans settled the archipelago in the mid-Holocene, around 6,000 years ago.

A large number of arthropods are associated with sloths. These include biting and blood-sucking flies such as mosquitoes and sandflies, triatomine bugs, lice, ticks and mites. The sloth’s fur forms a micro-ecozone inhabited by green algae and hundreds of insects. Sloths have a highly specific community of commensal beetles, mites and moths.

The three-toed sloths are arboreal neotropical mammals. They are the only members of the genus Bradypus and the family Bradypodidae. The four living species of three-toed sloths are the brown-throated sloth, the maned sloth, the pale-throated sloth, and the pygmy three-toed sloth. In complete contrast to past morphological studies, which tended to place Bradypus as the sister group to all other folivorans, molecular studies place them nested within the sloth superfamily Megatherioidea, making them the only surviving members of that radiation.

The brown-throated sloth is a species of three-toed sloth found in the Neotropical realm of Central and South America.

Choloepus is a genus of xenarthran mammals of Central and South America within the monotypic family Choloepodidae, consisting of two-toed sloths. The two species of Choloepus, Linnaeus's two-toed sloth and Hoffmann's two-toed sloth, were formerly believed on the basis of morphological studies to be the only surviving members of the sloth family Megalonychidae, but have now been shown by molecular results to be closest to extinct ground sloths of the family Mylodontidae.

Rebecca Cliffe is a British zoologist and one of the leading experts on sloth biology and ecology. She is the Founder and Executive Director of The Sloth Conservation Foundation and author of the book Sloths: Life in the Slow Lane with photographs by award-winning wildlife photographer Suzi Eszterhas.

Hoffmann's two-toed sloth is a species of sloth from Central and South America.

Linnaeus's two-toed sloth, also known as the southern two-toed sloth, unau, or Linne's two-toed sloth is a species of sloth from South America, found in Venezuela, the Guyanas, Colombia, Ecuador, Peru, and Brazil north of the Amazon River. There is now evidence suggesting the species' range expands into Bolivia.
The maned sloth is a three-toed sloth that lives only in Brazil. It is one of four species of three-toed sloth.

Megalonychidae is a group of sloths including the extinct Megalonyx. Megalonychids first appeared in the early Oligocene, about 35 million years (Ma) ago, in southern Argentina (Patagonia). There is actually one possible find dating to the Eocene, about 40 Ma ago, on Seymour Island in Antarctica. They first reached North America by island-hopping across the Central American Seaway, about 9 million years ago, prior to formation of the Isthmus of Panama about 2.7 million years ago. Some megalonychid lineages increased in size as time passed. The first species of these were small and may have been partly tree-dwelling, whereas the Pliocene species were already approximately half the size of the huge Late Pleistocene Megalonyx jeffersonii from the last ice age.

The pale-throated sloth, occasionally known as the ai, is a species of three-toed sloth that inhabits tropical rainforests in northern South America.

The "Panama Creature" refers to a carcass photographed near the town of Cerro Azul, Panama, in September 2009. After the animal was discovered and reputedly killed by a group of teenagers, photographs of the corpse were given to Telemetro, a Panamanian television station. The story and pictures circulated, and comparisons to the Montauk Monster were made. There was speculation about the identity of the creature, with suggestions including a hairless sloth, an alien species and a creature new to science. A biopsy performed by the National Environmental Authority of Panama on the remains a few days after the creature's discovery concluded that the corpse was in fact that of a male brown-throated sloth. The odd appearance had been caused by underwater decomposition, which had resulted in hair loss. Once identified, the corpse was buried.

The pygmy three-toed sloth, also known as the monk sloth or dwarf sloth, is a sloth endemic to Isla Escudo de Veraguas, a small island off the coast of Panama. The species was first described by Robert P. Anderson of the University of Kansas and Charles O. Handley Jr., of the Smithsonian Institution in 2001. The pygmy three-toed sloth is significantly smaller than the other three members of its genus, but otherwise resembles the brown-throated three-toed sloth. According to Anderson and Handley Jr., the head-and-body length is between 48 and 53 centimetres, and the body mass ranges from 2.5 to 3.5 kg.

A sloth moth is a coprophagous moth which has evolved to exclusively inhabit the fur of sloths and to use sloth dung as a substrate for the early stages of reproduction. Sloth moths include Bradypodicola hahneli, Cryptoses choloepi, Cryptoses waagei, Cryptoses rufipictus, and Bradypophila garbei.

The Sloth Conservation Foundation (SloCo) is a non-profit organisation based in Costa Rica that is dedicated to the protection of sloths living in wild and human-modified habitats through research, education and community-based conservation. SloCo was founded in 2017 by sloth researcher Dr. Rebecca Cliffe.

The three-toed sloths are arboreal neotropical mammals. They are the only members of the genus Bradypus and the family Bradypodidae. The four living species of three-toed sloths are the brown-throated sloth, the maned sloth, the pale-throated sloth, and the pygmy three-toed sloth. In complete contrast to past morphological studies, which tended to place Bradypus as the sister group to all other folivorans, molecular studies place them nested within the sloth superfamily Megatherioidea, making them the only surviving members of that radiation.

Choloepus is a genus of xenarthran mammals of Central and South America within the monotypic family Choloepodidae, consisting of two-toed sloths. The two species of Choloepus, Linnaeus's two-toed sloth and Hoffmann's two-toed sloth, were formerly believed on the basis of morphological studies to be the only surviving members of the sloth family Megalonychidae, but have now been shown by molecular results to be closest to extinct ground sloths of the family Mylodontidae.