
Glyptodonts are an extinct clade of large, heavily armoured armadillos. They arose in South America around 20 million years ago and spread to southern North America after the continents became connected several million years ago. The best-known genus within the group is Glyptodon.

Megatheriidae is a family of extinct ground sloths that lived from approximately 23 mya—11,000 years ago.

Mylodontidae is a family of extinct South American and North American ground sloths within the suborder Folivora of order Pilosa, living from around 23 million years ago (Mya) to 11,000 years ago. This family is most closely related to another family of extinct ground sloths, Scelidotheriidae, as well as to the extant arboreal two-toed sloths, family Choloepodidae; together these make up the superfamily Mylodontoidea. Phylogenetic analyses based on morphology uncovered the relationship between Mylodontidae and Scelidotheriidae; in fact, the latter was for a time considered a subfamily of mylodontids. However, molecular sequence comparisons were needed for the correct placement of Choloepodidae. These studies have been carried out using mitochondrial DNA sequences as well as with collagen amino acid sequences. The latter results indicate that Choloepodidae is closer to Mylodontidae than Scelidotheriidae is. The only other living sloth family, Bradypodidae, belongs to a different sloth radiation, Megatherioidea.

Nothrotheriidae is a family of extinct ground sloths that lived from approximately 11.6 mya—11,000 years ago, existing for approximately 11.49 million years. Previously placed within the tribe Nothrotheriini or subfamily Nothrotheriinae within Megatheriidae, they are now usually placed in their own family, Nothrotheriidae. Nothrotheriids appeared in the Tortonian, some 11.6 million years ago, in South America. The group includes the comparatively slightly built Nothrotheriops, which reached a length of about 2.75 metres (9.0 ft). While nothrotheriids were small compared to some of their megatheriid relatives, their claws provided an effective defense against predators, like those of larger anteaters today.

Pampatheriidae is an extinct family of large plantigrade armored xenarthrans related to armadillos. However, pampatheriids have existed as a separate lineage since at least the middle Eocene Mustersan age, 45 to 48 million years ago. Pampatheres evolved in South America during its long period of Cenozoic isolation. Although widespread, they were less diverse and abundant than the armadillos. Holmesina spread to North America after the formation of the Isthmus of Panama as part of the Great American Interchange. They finally disappeared on both continents in the end-Pleistocene extinctions, about 12,000 years ago.

Boreostemma is an extinct genus of glyptodonts from northern South America. Fossils assigned to the genus were first described as belonging to Asterostemma from southern South America, but have been placed in the new genus Boreostemma by Carlini et al. in 2008. The type species is B. pliocena. Fossils of Boreostemma have been found in the Honda Group of Colombia, in Peru and Venezuela.

Eionaletherium is an extinct genus of ground sloth from the Late Miocene coasts of Venezuela containing one species: E. tanycnemius.

Eleutherocercus was a genus of glyptodonts that lived during the Late Miocene and Early Pliocene in South America. Fossils of the genus have been found in the Huayquerian Ituzaingó Formation and the Montehermosan Monte Hermoso Formation in Argentina.

Euphractinae is an armadillo subfamily in the family Chlamyphoridae.

Ground sloths are a diverse group of extinct sloths, in the mammalian superorder Xenarthra. The term is used as a reference for all extinct sloths because of the large size of the earliest forms discovered, as opposed to existing tree sloths. The Caribbean ground sloths, the most recent survivors, lived in the Antilles, possibly until 1550 BCE. However, radiocarbon dating suggests an age of between 2819 and 2660 BCE for the last occurrence of Megalocnus in Cuba. Ground sloths had been extinct on the mainland of North and South America for 10,000 years or more. They survived 5,000–6,000 years longer in the Caribbean than on the American mainland, which correlates with the later colonization of this area by humans.
Hapalops is an extinct genus of ground sloth from the Early to Late Miocene of Brazil, Bolivia, Colombia, and Argentina in South America.

Megalonyx is an extinct genus of ground sloths of the family Megalonychidae, native to North America during the Pliocene and Pleistocene epochs. It became extinct during the Quaternary extinction event at the end of the Rancholabrean of the Pleistocene, living from ~5 million to 11,000 years ago. The type species, M. jeffersonii, measured about 3 meters (9.8 ft) and weighed up to 1,000 kilograms (2,200 lb). Megalonyx is descended from Pliometanastes, a genus of ground sloth that had arrived in North America during the Late Miocene, prior to the Great American Biotic Interchange. Megalonyx had the widest distribution of any North American ground sloth, having a range encompassing most of the contiguous United States, extending as far north as Alaska during warm periods.
Nematherium is an extinct genus of ground sloth of the family Scelidotheriidae found in Argentina and Chile during the Middle Miocene epoch (Santacrucian). Fossils have been found in the Cura-Mallín Formation of Chile and the Santa Cruz and Sarmiento Formations of Argentina.
Pelecyodon is an extinct genus of ground sloths from the Early Miocene (Santacrucian) of South America. Fossils have been found in the Santa Cruz Formation in Argentina.
Peltephilus, the horned armadillo, is an extinct genus of dog-sized, armadillo xenarthran mammals which first inhabited Argentina during the Oligocene epoch, and became extinct in the Miocene epoch. Notably, the scutes on its head were so developed that they formed horns. Aside from the horned gophers of North America, it is the only known fossorial horned mammal.
Promegatherium is a genus of prehistoric xenarthrans that lived in Argentina, during the Late Miocene. This genus is regarded as closely related to the later, and more famous genus, Megatherium, hence the reference in the name. The first specimens of Promegatherium were originally described by the biologist Florentino Ameghino in 1887. Its known species are Promegatherium cabreri, P. nanum, P. parvulum, P. remulsum, and P. smaltatus. P. nanum was originally placed in the genus "Eomegatherium" before it was grouped together in Promegatherium.

Pronothrotherium is an extinct genus of ground sloths from South America. Fossils of Pronothrotherium have been found in the Ituzaingó Formation of Argentina.
Propalaehoplophorus, also written as Propalaeohoplophorus, is an extinct genus of glyptodont, which lived in South America during the Early Miocene epoch.

Scelidotheriidae is a family of extinct ground sloths within the order Pilosa, suborder Folivora and superfamily Mylodontoidea, related to the other extinct mylodontoid family, Mylodontidae, as well as to the living two-toed sloth family Choloepodidae. The only other extant family of the suborder Folivora is the distantly related Bradypodidae. Erected as the family Scelidotheriidae by Ameghino in 1889, the taxon was demoted to a subfamily by Gaudin in 1995. However, recent collagen sequence data indicates the group is less closely related to Mylodon and Lestodon than Choloepus is, and thus it has been elevated back to full family status by Presslee et al. (2019).

Stegotherium is an extinct genus of armadillo in the family Dasypodidae from Early Miocene Argentina.

Thalassocnus is an extinct genus of semiaquatic ground sloths from the Miocene and Pliocene of the Pacific South American coast. It is monotypic within the subfamily Thalassocninae. The five species—T. antiquus, T. natans, T. littoralis, T. carolomartini, and T. yuacensis—represent a chronospecies, a population gradually adapting to marine life in one direct lineage. They are the only known aquatic sloths. They have been found in the Pisco Formation of Peru and the Bahía Inglesa, Coquimbo, and Horcón formations of Chile. Thalassocninae has been placed in both the families Megatheriidae and Nothrotheriidae.

Thinobadistes is an extinct genus of ground sloth of the family Mylodontidae endemic to North America during the Miocene-Pliocene epochs (Hemphillian). It lived from 10.3—4.9 mya, existing for approximately 5.4 million years.