25 Nuclear pore complex

Aladin, also known as adracalin, is a nuclear envelope protein that in humans is encoded by the AAAS gene. It is named after the achalasia–addisonianism–alacrima syndrome which occurs when the gene is mutated.

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene. It anchors aladin to the nuclear pore complex.

A nuclear pore is a part of a large complex of proteins, known as a nuclear pore complex that spans the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are approximately 1,000 nuclear pore complexes (NPCs) in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in the life cycle. The human nuclear pore complex (hNPC) is a 110 megadalton (MDa) structure. The proteins that make up the nuclear pore complex are known as nucleoporins; each NPC contains at least 456 individual protein molecules and is composed of 34 distinct nucleoporin proteins.About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered tertiary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many phenylalanine—glycine repeats.

Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). The nuclear pore complex is a massive structure embedded in the nuclear envelope at sites where the inner and outer nuclear membranes fuse, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nuclear pores enable the passive and facilitated transport of molecules across the nuclear envelope. Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family. Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate. A single NPC is able to transport 60,000 protein molecules across the nuclear envelope every minute.

Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.

Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene.

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.

Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.

Nucleoporin 133 (Nup133) is a protein that in humans is encoded by the NUP133 gene.

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.

Nucleoporin 188 (Nup188) is a protein that in humans is encoded by the NUP188 gene.

Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.

Nuclear pore glycoprotein-210 (gp210) is an essential trafficking regulator in the eukaryotic nuclear pore complex. Gp-210 anchors the pore complex to the nuclear membrane. and protein tagging reveals its primarily located on the luminal side of double layer membrane at the pore. A single polypeptide motif of gp210 is responsible for sorting to nuclear membrane, and indicate the carboxyl tail of the protein is oriented toward the cytoplasmic side of the membrane.

Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene.

Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.

Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. It is also known as nucleoporin 358 (Nup358) since it is a member nucleoporin family that makes up the nuclear pore complex. RanBP2 has a mass of 358 kDa.

Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene.

Protein transport protein Sec31A is a protein that in humans is encoded by the SEC31A gene.