
First Lady is an unofficial title usually used for the wife, and occasionally used for the daughter or other female relative, of a non-monarchical head of state or chief executive. The term is also used to describe a woman seen to be at the top of her profession or art.

Ramabai Bhimrao Ambedkar was the first wife of B. R. Ambedkar, who said her support was instrumental in helping him pursue his higher education and his true potential. She has been the subject of a number of biographical movies and books. A number of landmarks across India have been named after her.

Savita Bhimrao Ambedkar, was an Indian social activist, doctor and the second wife of Babasaheb Ambedkar, the father of the Indian Constitution. Ambedkarites and Buddhists refer to her as Mai or Maisaheb, which stands for 'Mother' in Marathi language.

Cheng Hong is an English professor at the Capital University of Economics and Business.

Elena Cuza, also known under her semi-official title Elena Doamna, was a Moldavian, later Romanian noblewoman and philanthropist. She was princess consort of the United Principalities and the wife of Alexander John Cuza.

Deng Yingchao was the Chairwoman of the Chinese People's Political Consultative Conference from 1983 to 1988, a member of the Communist Party of China, and the wife of the first Chinese Premier, Zhou Enlai.
The Order of Gabriela Silang is an all-female order of the Philippines founded on September 19, 2003.

Jiang Qing, also known as Madame Mao, was a Chinese Communist Revolutionary, actress, and major political figure during the Cultural Revolution (1966–76). She was the fourth wife of Mao Zedong, the Chairman of the Communist Party and Paramount leader of China. She used the stage name Lan Ping (藍蘋) during her acting career, and was known by many other names. She married Mao in Yan'an in November 1938 and served as the inaugural "First Lady" of the People's Republic of China. Jiang Qing was best known for playing a major role in the Cultural Revolution and for forming the radical political alliance known as the "Gang of Four".

Sarah Kyolaba Tatu Namutebi Amin, also known by her stage name "Suicide Sarah", was a Ugandan dancer who was dictator Idi Amin's fifth and last-surviving wife. She met Amin when she was a 19-year-old go-go dancer and they married in 1975. The couple had three children but Kyolaba left Amin after he went into exile in 1979. She moved to England where she ran a restaurant and later a hair salon. She died from cancer in 2015.

Liu Yongqing, is the wife of Hu Jintao, the former General Secretary of the Chinese Communist Party and President of the People’s Republic of China.

Margaretha "Gret" Loewensberg is a Swiss architect and the wife of former Swiss Federal Councillor Moritz Leuenberger.
Lu Muzhen was the first wife of Chinese revolutionary Sun Yat-sen.

María Ana Carcelén de Guevara y Larrea-Zurbano, 5th Marquise of Villarocha and 7th Marquise of Solanda was an Ecuadorian aristocrat and the wife of the Venezuelan independence leader Antonio José de Sucre. She is considered the 1st First Lady of Bolivia.

Mirjana "Mira" Marković was a Serbian politician, academic and the wife of Yugoslav and Serbian president Slobodan Milošević.

Evelyn Ntoko Mase, later named Evelyn Rakeepile, was a South African nurse. She was the first wife of the anti-apartheid activist and future president Nelson Mandela, to whom she was married from 1944 to 1958.

Gladys Molefi Olebile Masire, Lady Masire was a Botswana teacher and political figure who served as the longest ruling First Lady of Botswana from 1980 until 1998.

LisaRaye McCoy, known as LisaRaye, is an American actress, model, businesswoman and fashion designer. McCoy is best known for portraying Diana "Diamond" Armstrong in the 1998 film The Players Club, Neesee James on the UPN/The CW sitcom All of Us from 2003 until 2007 and Keisha Greene in the VH1 romantic comedy series Single Ladies which originally aired from 2011 to 2014. She was also married to Michael Misick, the first-ever Premier of the Turks and Caicos Islands, from 2006 until 2008; during that time she served as First Lady of Turks and Caicos.

Sheikha Moza bint Nasser is the consort of Sheikh Hamad bin Khalifa Al Thani, former Emir of the State of Qatar.

Ida Betty Odinga is a Kenyan businesswoman, activist and educator. She is the wife of Raila Odinga, the former Prime Minister of Kenya. In 2010, The Standard named Odinga, who was one of the first women to head a major Kenyan company, as one of the top the most powerful women in Kenya in 2010.

Peng Liyuan is a Chinese contemporary folk singer who is the spouse of the President of the People's Republic of China. Peng Liyuan is married to the current General Secretary of the Chinese Communist Party and President Xi Jinping. Peng is referred to as the "Chinese First Lady" by Chinese media. During 2012 to 2017, Peng was the President of then People's Liberation Army Academy of Art, and from 2005 to 2010, served as Vice President of the All-China Youth Federation.

Bun Rany is a Cambodian humanitarian worker, nurse and, as the wife of long-time Cambodian Prime Minister Hun Sen, First Lady of Cambodia. She has served as the vice president of the National Association of the Cambodian Red Cross and, since 1998, as its president. She has received national and international recognition and numerous awards for her work with Cambodia's orphans and poor, HIV/AIDS awareness and prevention, and her emphasis on women's issues with efforts to improve domestic safety and empowerment through education and vocational training. Her full honorary title is Samdech Kittipritbandit Bun Rany Hun Sen.

Rachel Ruto is the wife of William Ruto, 1st Deputy President of Kenya and the Second Lady of Kenya. She was instrumental in assisting her husband's campaign, often seen by her husband's side.

Janet Duvenage Smith, CLM, was the wife of Ian Smith, Prime Minister of Rhodesia from 1964 to 1979. Born in Cape Town, South Africa, she studied history at the University of Cape Town and became a teacher. In 1942, she married Piet Duvenage, a rugby player, and had two children. He died in an accident on the rugby field in 1947. The next year, a short visit with family in Southern Rhodesia became permanent when she accepted a teaching job in Selukwe. There, she met her future husband, Ian Smith, who had recently come home from the Second World War. In 1948, the couple got married and bought a farm, and Ian was elected to the Southern Rhodesian Legislative Assembly.

Sajida Khairallah Talfah is the widow and cousin of former Iraqi President Saddam Hussein, and mother of two sons and three daughters. She is the oldest daughter of Khairallah Talfah, her husband's maternal uncle. She was played by Shohreh Aghdashloo in the BBC adaptation House of Saddam in 2008, in which her character played a major role.

Wang Guangmei was a Chinese politician, philanthropist and the wife of Liu Shaoqi, who served as the President of the People's Republic of China from 1959 to 1968.

Yáng Kāihuì was the second wife of Mao Zedong, whom he married in 1920. She had three children with Mao Zedong: Mao Anying, Mao Anqing, and Mao Anlong. Her father was Yang Changji, the head of the Hunan First Normal School and one of Mao’s favorite teachers.

Ye Qun was the wife of Lin Biao, the Vice-Chairman of China who controlled China's military power. She was mostly known for taking care of politics for her husband. Ye was a member of the 9th Politburo of the Communist Party of China. She died with Lin Biao and their son Lin Liguo in a plane crash over Mongolia on September 13, 1971. They also had a daughter, Lin Liheng (Doudou), who was not on the airplane.

Asif Ali Zardari is a Pakistani politician who is the president of Pakistan Peoples Party Parliamentarians and was the co-chairperson of Pakistan People's Party. He served as the 11th President of Pakistan from 2008 to 2013, the first president born after Partition. He is member of National Assembly of Pakistan since August 2018.