Inuka was a male polar bear and one of the mascots of the Singapore Zoo. Born and housed in a climate-controlled enclosure, he was the world's only "tropical polar bear".

Ch. K-Run's Park Me In First, also known as Uno was a 15-inch (380 mm) beagle from Belleville, Illinois, who won Best in Show in the 2008 Westminster Kennel Club dog show. He was the first beagle to claim the top prize at Westminster and the first beagle to win the hound group since 1939.

Keyboard Cat is a video-based internet meme. Its original form was a video originally made in 1984 by Charlie Schmidt of his cat Fatso seemingly playing a musical keyboard to a cheery tune. While Schmidt had uploaded the video himself to YouTube in 2007, Brad O'Farrell, with Schmidt's permission, appended the video to the end of a blooper video uploaded in 2009 as if to have the cat "play" the person offstage after the gaffe as they had done in Vaudeville. The idea of this quickly expanded on the Internet by numerous other users, typically under the name "Play Him Off, Keyboard Cat", and became a meme.

Hanabiko "Koko" was a female western lowland gorilla. Koko was born at the San Francisco Zoo and lived most of her life in Woodside, California, at The Gorilla Foundation's preserve in the Santa Cruz Mountains. The name "Hanabiko" (花火子), lit. ''fireworks child'', is of Japanese origin and is a reference to her date of birth, the Fourth of July. Koko gained public attention upon a report of her having adopted a kitten as a pet and creating a name for him.

Lucca was a German Shepherd/Belgian Malinois service dog who was employed by the United States Marine Corps for 6 years. She was trained to detect explosives. She was deployed twice to Iraq and once to Afghanistan. In her over 400 missions, no human fatalities occurred under her watch. In 2012, while on patrol in Afghanistan, she was injured by an IED blast, necessitating the amputation of her left leg. After recovering at Camp Pendleton, Lucca officially retired in 2012 and was adopted by her original handler, Gunnery Sergeant Chris Willingham.

Nico was a western lowland gorilla who lived in captivity at Longleat Safari Park, Wiltshire, UK. At the time of his death, at 56 years old, he was the oldest Western lowland gorilla in Europe and was thought to be the second oldest gorilla in the world. Nico's habitat on Half Mile Lake at Longleat covered over half an acre and included lookout stations, tree trunk climbing frames and tyre and net swings.

Sudan was a captive northern white rhinoceros that lived at the Dvůr Králové Zoo in the Czech Republic from 1975 to 2009, and the rest of his life at the Ol Pejeta Conservancy in Laikipia, Kenya. At the time of his death, he was one of only three living northern white rhinoceroses in the world, and the last known male of his subspecies. Sudan was euthanised on 19 March 2018, after suffering from "age-related complications".