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Achalasia microcephaly syndrome is a rare condition whereby achalasia in the oesophagus manifests alongside microcephaly and mental retardation. This is a rare constellation of symptoms with a predicted familial trend.

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Lester Green, better known by his stage name Beetlejuice, is a member of the The Howard Stern Show's Wack Pack, who was named the greatest Wack Packer of all time by Stern in 2015. He has also appeared in such feature films as Bubble Boy and Scary Movie 2.

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Jaxon Emmett Buell, was an American child known for being born missing about 80% of his brain due to microhydranencephaly. He surpassed all doctors' expectations, who predicted he would not live up to one year old. He lived for five years. When he turned one year old, his parents began posting updates about him on social media, which gained attention.

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Máximo and Bartola were the stage names of two Salvadoran siblings both suffering from microcephaly and cognitive developmental disability who were exhibited in human zoos in the 19th century. Originally from near Usulután, El Salvador, the siblings were given by their mother to a merchant who promised he would take them to Grenada to be educated and exhibited. They then went through several guardians afterwards. They were eventually billed as "Aztec Children" and an elaborate story was constructed of how they were found in the temple of a lost Mesoamerican city. They toured the U.S. and Europe, appearing before various regents and dignitaries.

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Schlitzie, possibly born Simon Metz and legally Schlitze Surtees, was an American sideshow performer. He also appeared in a few films, and is best known for his role in the 1932 movie Freaks. His lifelong career on the outdoor entertainment circuit as a major sideshow attraction with Barnum & Bailey, among others, made him a popular cultural icon.

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William Henry Johnson, known as Zip the Pinhead, was an American freak show performer famous for his tapered head.

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Zippy the Pinhead is a fictional character who is the protagonist of Zippy, an American comic strip created by Bill Griffith. Zippy's most famous quotation, "Are we having fun yet?", appears in Bartlett's Familiar Quotations and became a catchphrase. He almost always wears a yellow muumuu/clown suit with large red polka dots, and puffy, white clown shoes. Although in name and appearance, Zippy is a microcephalic, he is distinctive not so much for his skull shape, or for any identifiable form of brain damage, but for his enthusiasm for philosophical non sequiturs, verbal free association, and the pursuit of popular culture ephemera. His wholehearted devotion to random artifacts satirizes the excesses of consumerism.