Machaeroidinae ("dagger-like") is a subfamily of extinct carnivorous sabre-toothed eutherian mammals from Asia and North America. Traditionally classified as hyaenodonts, this group is now classified as a member of the family Oxyaenidae.

Oxyaenidae is a family of extinct carnivorous placental mammals. Traditionally classified in order Creodonta, this group is now classified in its own order Oxyaenodonta within mirorder Ferae. The group contains four subfamilies comprising fourteen genera. Oxyaenids were the first to appear during the late Paleocene in North America, while smaller radiations of oxyaenids in Europe and Asia occurred during the Eocene.

Oxyaeninae is a extinct subfamily of oxyaenids from the late Paleocene to late Eocene of Asia, Europe and North America.
Machaeroides ("dagger-like") is a genus of sabre-toothed predatory mammal that lived during the Eocene. Its fossils were found in the U.S. state of Wyoming.

Oxyaena is an extinct genus of oxyaenid mammal from early Eocene of Europe, Asia and North America.

Palaeonictis is an extinct predatory mammal belonging to the family Oxyaenidae, existing from the late Paleocene to the early Eocene in Europe and North America.

Patriofelis was a large, cat-like oxyaenid of middle Eocene in North America. It was around 1.2 to 1.8 metres long, not including the tail, and weighed about 40–90 kg, making it around the same size as a modern cougar. It had short legs with broad feet, suggesting that it may have been a poor runner, but a quite good swimmer. As its close relative Oxyaena was a reasonably good climber, it is possible Patriofelis could climb as well. It is found in particular in the Bridger Basin of southwestern Wyoming and at John Day Fossil Beds National Monument, in the U.S. state of Oregon.

Sarkastodon is an extinct genus of mammal within the creodont family Oxyaenidae that lived during the early to late Eocene, 48.6 to 37.2 million years ago. It was a large, carnivorous animal that lived in what is today China and Mongolia. Sarkastodon is known only from a skull and jawbones. Sarkastodon was probably a hypercarnivore that preyed on large mammals in its range during the Late Eocene, such as brontotheres, chalicotheres, and rhinoceroses. Its weight is estimated at 800 kg (1,800 lb), and its length at 3 m (10 ft).

Tytthaena is an extinct genus of oxyaenid from the late Paleocene to early Eocene of North America. Two species are known, T. parrisi and T. lichna.