
Alejandro de Humboldt National Park is a national park in the Cuban provinces of Holguín and Guantánamo. It is named after the German scientist Alexander von Humboldt who visited the island in 1800 and 1801. The park was inscribed as a UNESCO World Heritage Site in 2001 for of its size, altitude range, complex lithology, landform diversity, and wealth of endemic flora and fauna.

Cape Maisí or Cape Maysí is a cape at the eastern extremity of Cuba, projecting into the Windward Passage. It lies in the municipality of Maisí, Guantánamo Province.

Cuchillas del Toa is a Biosphere Reserve in Cuba. It is located in the eastern part of the country, mostly in the Guantánamo Province and reaching to the north into the Holguín Province. Most of the reserve is established in the drainage area of the Toa River, which flows for 118 km (73 mi) to the Atlantic Ocean in Baracoa.

El Yunque is a 575-metre-high (1,886 ft) mountain located 7 km (4.3 mi) west of Baracoa and the Baracoa Bay in Cuba's Guantanamo Province. It has a table mountain shape that resembles an anvil.

The Imías Formation is a geologic formation in Cuba. It preserves fossils dating back to the Miocene period.

Guantánamo Bay is a bay located in Guantánamo Province at the southeastern end of Cuba. It is the largest harbor on the south side of the island and it is surrounded by steep hills which create an enclave that is cut off from its immediate hinterland.

Guantanamo Bay Naval Base, officially known as Naval Station Guantanamo Bay or NSGB, is a United States military base on the shore of Guantánamo Bay and is also the oldest overseas U.S. Naval Base. The base is located on 45 square miles (116 km2) of land and water at Guantánamo Bay, at the southeastern end of Cuba, which the U.S. leased for use as a coaling station and naval base in 1903. The lease was $2,000 in gold per year until 1934, when the payment was set to match the value in gold in dollars; in 1974, the yearly lease was set to $4,085.

Guantánamo River is a river of southern Cuba, that flows Province of Guantánamo up to Guantanamo Bay. It is impounded by La Yaya Dam.

Nipe-Sagua-Baracoa, also known as Macizo Nipe Sagua Baracoa, is a mountain range of eastern Cuba.

The Old Bahama Channel is a strait of the Caribbean region, between Cuba and the Bahamas.

Sierra Maestra is a mountain range that runs westward across the south of the old Oriente Province in southeast Cuba, rising abruptly from the coast. The Sierra Maestra itself is located mainly in Santiago de Cuba Province and in Granma Province. Some view it as a series of connecting ranges, which joins with others extending to the west. The Sierra Maestra is the highest area of Cuba. It is rich in minerals, especially copper, manganese, chromium, and iron. At 1,974 m (6,476 ft), Pico Turquino is the range's highest point.