
The regions of Ghana constitute the first level of subnational government administration within the Republic of Ghana. There are currently sixteen regions, further divided for administrative purposes into 216 local districts.

The Ahafo Region is a newly created Region in Ghana with Goaso as its capital. The region had administrative and governmental legislature like all the ten already existing regions in Ghana. The region was carved out of the south-eastern part of the Brong Ahafo Region and was in fulfillment of a campaign promise made by New Patriotic Party. Prior to the 2016 Ghanaian general election, the then candidate Nana Akufo-Addo declared that when elected, he would explore the possibility of creating new regions out of some of the existing regions in Ghana in order to bring government closer to citizens.

The Ashanti Region is located in south Ghana and is third largest of 16 administrative regions, occupying a total land surface of 24,389 km2 (9,417 sq mi) or 10.2 per cent of the total land area of Ghana. In terms of population, however, it is the most populated region with a population of 4,780,380 according to the 2011 census, accounting for 19.4% of Ghana's total population. The Ashanti Region is known for its major gold bar and cocoa production. The largest city and regional capital is Kumasi.

The Bono East region of Ghana is a new region carved out of the existing Brong Ahafo region. The capital of the new region is Techiman. This creation of this new region was in fulfillment of a promise made by the New Patriotic Party prior to the 2016 Ghana general election. Upon winning the elections, the President, Nana Akuffo Addo created the Ministry of Regional Reorganization to oversee policy formulation and implementation. In all six new regions are to be created from the existing ten regions of Ghana. The other regions are Bono, Western North, Ahafo, Savannah, North East, and Oti regions.

The Bono region is one of the 16 administrative regions of Ghana. It is as a result of the remainder of Brong-Ahafo region when Bono East region and Ahafo region were created. Sunyani, also known as the green city of Ghana is the regional capital. Sunyani can pride itself as the cleanest capital city and a major conference destination.

The Brong-Ahafo region was a region in southern Ghana. Brong-Ahafo was bordered to the north by the Black Volta river and to the east by the Lake Volta, and to the south by the Ashanti, Eastern and Western regions. The capital of Brong-Ahafo is Sunyani. Brong-Ahafo was created on 14 April 1959 from the then Western Ashanti and named after the dominant and native inhabitants, Akans, Brong and Ahafo. In 2019, as a result of the 2018 Ghanaian new regions referendum, the region was divided into three, namely Bono, Bono East and Ahafo regions, and ceased to exist.

The Central Region is one of the sixteen administrative regions of Ghana. It is bordered by Ashanti and Eastern regions to the north, Western region to the west, Greater Accra region to the east, and to the south by the Gulf of Guinea. The Central region is renowned for its many elite higher education institutions and an economy based on an abundance of industrial minerals and tourism. The Central region attains many tourist attractions such as castles, forts and beaches stretched along the Central region's coastline.

The Eastern Region is located in south Ghana and is one of the sixteen administrative regions of Ghana. Eastern region is bordered to the east by the Lake Volta, to the north by Bono East Region and Ashanti region, to the west by Ashanti region, to the south by Central region and Greater Accra Region. Akans are the dominant inhabitants and natives of Eastern region and Akan, Ewe, Krobo, Hausa and English are the main spoken languages. The capital town of Eastern Region is Koforidua.The Eastern region is the location of the Akosombo dam and the economy of the Eastern region is dominated by its high-capacity electricity generation. Eastern region covers an area of 19,323 square kilometres, which is about 8.1% of Ghana's total landform.

The Greater Accra Region has the smallest area of Ghana's 16 administrative regions, occupying a total land surface of 3,245 square kilometres. This is 1.4 per cent of the total land area of Ghana. It is the second most populated region, after the Ashanti Region, with a population of 4,010,054 in 2010, accounting for 16.3 per cent of Ghana's total population.

The North East Region is one of the sixteen regions of Ghana. It is located in the north of the country and was created in December 2018 after a referendum was voted upon to break it off of the Northern region. The region's capital is Nalerigu.

The Northern Region is one of the sixteen regions of Ghana. It is located in the north of the country and was the largest of the sixteen regions, covering an area of 70,384 square kilometres or 31 percent of Ghana's area until December 2018 when the Savannah Region and North East Regions were created from it. The Northern Region is divided into 14 districts. The region's capital is Tamale.

The Oti Region is one of the six regions created regions of Ghana in December 2018. The region was carved out of the northern part of the Volta Region and will be in fulfillment of a campaign promise made by New Patriotic Party. Prior to the 2016 Ghanaian general election, the then candidate Nana Akufo-Addo declared that when elected, he would explore the possibility of creating new regions out of some of the existing regions in Ghana in order to bring government closer to citizens.
The Savannah Region is one of the newest regions of Ghana and yet the largest region in the country. The creation of the Region follows presentation of a petition by the Gonja Traditional Council, led by the Yagbonwura Tumtumba Boresa Jakpa I. Upon receiving favourable responses from all stakeholders in the Northern Region, the Brobbey Commission, a referendum was conducted on the 27th December 2018. The result was a resounding yes of 99.7%. The President of the Republic of Ghana signed and presented the Constitutional Instrument (CI) 115 to the Yagbonwura in the Jubilee House, Accra on 12 February 2019. The launch was well attended by sons and daughters of Gonjaland including all current and past Mps, MDCEs and all appointees with Gonjaland descent. Damongo was declared the capital of the new Savannah Region. It is located in the north of the country. The Savannah Region is divided into 7 districts; Bole, Central Gonja, North Gonja, East Gonja, Sawla/Tuna/Kalba, West Gonja, North East Gonja and 7 Constituencies; Bole/Bamboi, Damongo, Daboya/Mankarigu, Salaga North, Salaga South, Sawla/Tuna/Kalba and Yapei/Kusawgu.
The Upper East Region is located in north Ghana and is the second smallest of 10 now 16 administrative regions in Ghana, occupying a total land surface of 8,842 square kilometers or 2.7 per cent of the total land area of Ghana. The Upper East regional capital is Bolgatanga, sometimes referred to as Bolga. Other major towns in the region include Navrongo, Paga, Bawku and Zebilla.

The Upper West Region of Ghana is located in the north-western corner of Ghana and is bordered by Upper East region to the east, Northern region to the south, and Burkina Faso to the west and north. The Upper West regional capital and largest settlement is Wa. Upper West is the youngest region, created in Ghana by the then Head of State, Flight-Lieutenant Jerry Rawlings in 1983 under the Provisional National Defense Council (PNDC). The area was carved out of the former Upper Region, which is now the Upper East Region.

Volta Region, is one of Ghana's sixteen administrative regions, with Ho designated as its capital. It is located west of Republic of Togo and to the east of Lake Volta. Divided into 25 administrative districts, the region is multi-ethnic and multilingual, including groups such as the Ewe, the Guan, and the Akan peoples. The Guan peoples include the Lolobi, Likpe, Akpafu, Buem, and Nkonya people, et al. This region was carved out of the Volta Region in December 2018 by the New Patriotic Party
The Western North Region is one of the six new regions of Ghana created in 2019. The region is bounded by the Ivory Coast on the west, the Central region in the southeast, and the Ashanti, Ahafo, Bono East and Bono regions in the north. The Western North Region has the highest rainfall in Ghana, lush green hills, and fertile soils. There are numerous small and large-scale gold mines companies in the region. The ethnic culture of the region is dominated by the Sefwis. The main languages spoken are Sefwi, Akan, French and English.

The Western Region is located in south Ghana, spreads from the Ivory Coast in the west to the Central region in the east, includes the capital and large twin city of Sekondi-Takoradi on the coast, coastal Axim, and a hilly inland area including Elubo. It includes Ghana's southernmost location, Cape Three Points, where crude oil was discovered in commercial quantities in June 2007. The region covers an area of 23,921 sq. km, and had a population of 2,376,021 at the 2010 Census; the latest official projected population is 3,093,201.

Western Togoland is an area de jure in the Republic of Ghana. The area of Western Togoland is divided into five regions: Volta, Oti, Northern region, North East region and Upper East Region. In September 2020 separatists in Western Togoland declared independence from the Republic of Ghana.