
During the 1980s, then Peruvian president Alan García proposed what was supposed to be a radical restructuring of the political and economical divisions of the country: regionalization. The law, which was approved, mandated the creation of regions to function eventually as autonomous economic and administrative entities; 12 regions were formed from 23 of the former 24 departments. Formation of another region was delayed by the reluctance of the Constitutional Province of Callao to merge with the Lima Department. Originally San Martín and La Libertad Regions formed the sole region of San Martín-La Libertad but later were split.

The following is a list of the regions of Peru ordered by population from Census 2007 and estimated population of INEI.

According to the Organic Law of Regional Governments, the regions are, with the departments, the first-level administrative subdivisions of Peru. Since its 1821 independence, Peru had been divided into departments but faced the problem of increasing centralization of political and economic power in its capital, Lima.

Amazonas is a department of northern Peru bordered by Ecuador on the north and west, Cajamarca on the west, La Libertad on the south, and Loreto and San Martín on the east. Its capital is the city of Chachapoyas.

Ancash is a department of northern Peru. It is bordered by the departments of La Libertad on the north, Huánuco and Pasco on the east, Lima on the south, and the Pacific Ocean on the west. Its capital is the city of Huaraz, and its largest city and port is Chimbote. The name of the region originates from the Quechua word anqash, from anqas (blue) or from anka (eagle).

Apurímac is a region in southern-central Peru. It is bordered on the east by the Cusco Region, on the west by the Ayacucho Region, and on the south by the Arequipa and Ayacucho regions. The region's name originates from the Quechua language and means "where the gods speak" in reference to the many mountains of the region that seem to be talking to each other.

Arequipa is a department in southwestern Peru. It is the sixth largest department in Peru, after Puno, Cuzco, Madre de Dios, Ucayali, and Loreto, its sixth most populous department, and its eleventh least densely populated department. It is bordered by the departments of Ica, Ayacucho, Apurímac and Cusco in the north, the Department of Puno in the east, the Department of Moquegua in the south, and the Pacific Ocean in the west. Its capital, also called Arequipa, is Peru's second-largest city.

Ayacucho is a department of Peru, located in the south-central Andes of the country. Its capital is the city of Ayacucho. The region was one of the hardest hit by terrorism in the 1980s during the guerrilla war waged by Shining Path known as the internal conflict in Peru.

Cajamarca is a department in Peru. The capital is the city of Cajamarca. It is located in the north part of the country and shares a border with Ecuador. The city has an elevation of 2,700 metres (8,900 ft) above sea level in the Andes Mountain Range, the longest mountain range in the world. Part of its territory includes the Amazon Rainforest, the largest in the world.

Callao is a seaside city on the Pacific Ocean in the Lima metropolitan area. Callao is Peru's chief seaport and home to its main airport, Jorge Chávez International Airport. Callao municipality consists of the whole Callao Region, which is also coterminous with the Province of Callao. Founded in 1537 by the Spanish, the city has a long naval history as one of the main ports in Latin America and the Pacific, as it was one of vital Spanish towns during the colonial era. Central Callao is about 15 km (9.3 mi) west of the Historic Centre of Lima.

Cusco, also spelled Cuzco, is a department in Peru and is the fourth largest department in the country, after Madre de Dios, Ucayali, and Loreto. It borders the departments of Ucayali on the north; Madre de Dios and Puno on the east; Arequipa on the south; and Apurímac, Ayacucho and Junín on the west. Its capital is Cusco, the historical capital of the Inca Empire.

Ica is a department in Peru. It borders the Pacific Ocean on the west; the Lima Region on the north; the Huancavelica and Ayacucho regions on the east; and the Arequipa Region on the south. Its capital is the city of Ica.

La Libertad is a region in northwestern Peru. Formerly it was known as the Department of La Libertad. It is bordered by the Lambayeque, Cajamarca and Amazonas regions on the north, the San Martín Region on the east, the Ancash and Huánuco regions on the south and the Pacific Ocean on the west. Its capital is Trujillo, which is the nation's third biggest city. The region's main port is Salaverry, one of Peru's largest ports. The name of the region is Spanish for "freedom" or "liberty"; it was named in honor of the Intendencia of Trujillo's proclaiming independence from Spain in 1820 and fighting for that. It is the ninth smallest department in Peru, but it is also its second most populous department after Piura and its second most densely populated department after Lambayeque.

Lambayeque is a department in northwestern Peru known for its rich Moche and Chimú historical past. The region's name originates from the ancient pre-Inca civilization of the Lambayeque. It is the second-smallest department in Peru after Tumbes, but it is also its most densely populated department and its eighth most populous department.

The Department of Lima is located in the central coast of Peru, its regional seat is Huacho.

Loreto is Peru's northernmost department. Covering almost one-third of Peru's territory, Loreto is by far the nation's largest department; it is also one of the most sparsely populated regions due to its remote location in the Amazon Rainforest. Its capital is Iquitos.

Madre de Dios is a department in southeastern Peru, bordering Brazil, Bolivia and the Peruvian departments of Puno, Cusco and Ucayali, in the Amazon Basin. Its capital is the city of Puerto Maldonado. It is also the third largest department in Peru, after Ucayali and Loreto. However, it is also the least densely populated department in Peru, as well as its least populous department.

Moquegua is a department in southern Peru that extends from the coast to the highlands. Its capital is the city of Moquegua, which is among the main Peruvian cities for its high rates of GDP and national education.

Pasco is a region in central Peru. Its capital is Cerro de Pasco.
Piura is a coastal region in northwestern Peru. The region's capital is Piura and its largest port cities, Paita and Talara, are also among the most important in Peru. The area is known for its tropical and dry beaches. It is the most populous department in Peru, its twelfth smallest department, and its fourth-most densely populated department, after Tumbes, La Libertad, and Lambayeque.

Puno is a department in southeastern Peru. It is the fifth largest department in Peru, after Cuzco, Madre de Dios, Ucayali, and Loreto It is bordered by Bolivia on the east, the departments of Madre de Dios on the north, Cusco and Arequipa on the west, Moquegua on the southwest, and Tacna on the south. Its capital is the city of Puno, which is located on Lake Titicaca in the geographical region known as the Altiplano or high sierra.

Tacna is the southernmost department in Peru. The Chilean Army occupied the present-day Tacna Department during the War of the Pacific from 1885 to 1929 when it was reincorporated into Peruvian soil; today, it is known for being one of the most patriotic areas in the country.

Tumbes is a coastal region in northwestern Peru and southwestern Ecuador. Due to the region's location near the Equator it has a warm climate, with beaches that are considered among the finest in Peru. Despite its small area, the region contains a wide variety of ecosystems. It is the smallest department in Peru and its third least populous department after Moquegua and Madre de Dios, but it is also its third most densely populated department, after La Libertad and Lambayeque.

Ucayali is an inland department of Peru. Located in the Amazon rainforest, its name is derived from the Ucayali River. Its capital is the city of Pucallpa. It is the second largest department in Peru, after Loreto.

Huancavelica is a department in Peru with an area of 22,131.47 km2 (8,545.01 sq mi) and a population of 347,639. The capital is the city Huancavelica. The region is bordered by the departments of Lima and Ica in the west, Junín in the north, and Ayacucho in the east.

Huánuco is a department in central Peru. It is bordered by the La Libertad, San Martín, Loreto and Ucayali regions in the north, the Ucayali Region in the east, the Pasco Region in the south and the Lima and Ancash regions in the west. Its capital is the city Huánuco.

Junín is a region in the central highlands and westernmost Peruvian Amazon. Its capital is Huancayo.
San Martín is a department in northern Peru. Most of the department is located in the upper part of the Peruvian Amazon rainforest. Its capital is Moyobamba and the largest city in the department is Tarapoto.

Tres Fronteras is the Spanish name for an area of the Amazon Rainforest in the Upper Amazon region of South America.

The Yungas is a narrow band of forest along the eastern slope of the Andes Mountains from Peru, Bolivia, and northern Argentina. It is a transitional zone between the Andean highlands and the eastern forests. Like the surrounding areas, the Yungas belong to the Neotropical realm; the climate is rainy, humid, and warm.