
Cacheu is a region in western Guinea-Bissau, on the border with Senegal. It has an area of 5,175 km2 and a population estimated in 2004 at 164,676. Its capital is Cacheu. There has not been any local administration since the civil war of 1998-99 and all the social services are done by organs of civil society and other government agencies. It is a coastal region covered with Mangrove swamps, rain forest and tangled forest and receives an annual rainfall of more than 1,000 mm (39 in)

Antotinha is a village in the Cacheu Region of northwestern Guinea-Bissau. It lies to the north of the Cacheu River, north and across the river from São Vicente.

Cacheu is a town in northwestern Guinea-Bissau, lying on the Cacheu River. Its population was estimated to be 9,849 as of 2008.

The Cacheu River Mangroves Natural Park is a national park situated on the Cacheu River in Guinea-Bissau. It was established on 1 December 2000. This site is 886 km2. The park has been designated as a Ramsar site since 2015.

Jolmete is a village in the Cacheu Region of northwestern Guinea-Bissau. It lies to the south of the Cacheu River.

Pecixe is an island in Guinea-Bissau. It is a coastal island belonging to the Cacheu Region and the Caió sector. Its area is 167 km². The island has a population of 3,207 ; the largest village is Cassaca. The language of the island is reported to be Mandjak, a language of Guinea-Bissau with over 72,000 speakers altogether. Jeta island lies to the west. It is 3 km off the mainland, about 50 km west of the capital city Bissau.

São Vicente is a village in the Cacheu Region of north-western Guinea-Bissau. It lies on the southern bank of the Cacheu River, to the east of Jolmete.