
Cuajimalpa de Morelos is one of the 16 boroughs of Mexico City. It is located on the west side of the city in the Sierra de las Cruces mountains which separate Mexico City from the State of Mexico. The borough is named after the former rural town of Cuajimalpa, which has since been absorbed by urban sprawl. The borough is home to the Desierto de los Leones National Park, the first declared in Mexico as well as the second largest annual passion play in Mexico City.

Bosques de las Lomas is a colonia, or officially recognised neighbourhood, located in western Mexico City. It falls partly in Cuajimalpa borough and partly in Miguel Hidalgo borough.

Centro Santa Fe, often incorrectly named "Centro Comercial Santa Fe", is a large 210,400-square-metre (2,264,727 sq ft) enclosed shopping mall in the Santa Fe area of Cuajimalpa, Mexico City. Centro Santa Fe is the largest shopping center in Mexico. The original mall, 128,367 m2 (1,381,730 sq ft), cost 270 billion old Mexican pesos in 1993. It was further expanded in 2012.

The Colegio Israelita de México A.C., providing services as Colegio Israelita de México ORT, is a private K-12 school in Lomas de Vista Hermosa, Cuajimalpa, Mexico City. It is also known by its acronym, CIM, or as the Idishe, the first word in its Yiddish name.

Desierto de los Leones National Park is located entirely within the limits of the Federal District; it stretches between Cuajimalpa and Álvaro Obregón boroughs. It is located in the Sierra de las Cruces mountain range west of the city center with an area of 1,867 hectares, representing fifteen percent of the entire Valley of Mexico. The term Desierto (‘desert’) is used in this context in the archaic sense of “wild, sparsely populated area” rather than in reference to an arid environment. Leones (‘Lions’) refers not to the big cats but rather to the original landlord's surname.

El Puerto de Liverpool S.A.B. de C.V., commonly known as Liverpool, is a mid-to-high end retailer which operates the largest chain of department stores in Mexico. It operates 136 stores under the Liverpool name, 131 stores under the Suburbia name, and 27 shopping centers, including Perisur and Galerías Monterrey.

Santa Fe is one of Mexico City's major business districts, located in the west part of the city in the alcaldías (boroughs) of Cuajimalpa and Álvaro Obregón. The Paseo de la Reforma avenue and Constituyentes avenue are the primary means of access to the district from the central part of Mexico City. Santa Fe consists mainly of highrise buildings surrounding a large shopping mall, Centro Santa Fe, which is currently the largest mall in Latin America. The district also includes a residential area and three university campuses, among other facilities.The Toluca–Mexico City commuter rail, due to open in 2020, will also improve mobility and development in the district.