
The Appenweier–Strasbourg railway is a major railway line linking the French TGV station at Strasbourg with the German Rhine Valley Railway (Rheintalbahn) and the Karlsruhe–Basel high-speed railway. The line is almost entirely double-tracked and fully electrified. The section between Kehl and Appenweier is undergoing a modernisation with the goal of a maximum speed of 200 km/h. The French section is owned by SNCF, the German section is owned by Deutsche Bahn.

The Freiburg–Colmar railway was an international railway that formerly connected Freiburg im Breisgau, in the German state of Baden-Württemberg, with Colmar, in the French department of Haut-Rhin. The line crossed the river Rhine on a bridge between Breisach and Neuf-Brisach. Since that bridge was destroyed in 1945, the line from Freiburg has terminated at Breisach, and this stretch of line is now commonly called the Freiburg–Breisach railway, or the Breisacherbahn. The section from Freiburg to Breisach was completed in 1871 and the remainder in 1878.

The Müllheim–Mulhouse railway is a 22.140 km-long single-track railway, crossing the Upper Rhine between Baden, Germany and Alsace, France. The whole line is electrified with catenary, using different national electrification standards on either side of the Rhine. It branches off the Rhine Valley Railway (Rheintalbahn) in Müllheim and it connects with the Paris–Mulhouse railway and the Strasbourg–Basel railway in Mulhouse.
The Neuchâtel–Pontarlier railway, also known as the Val-de-Travers line or the Franco-Suisse (Franco-Swiss) line, is a single-track standard-gauge railway line run by the Swiss Federal Railways (SBB) and the French public railway infrastructure company Réseau ferré de France (RFF).

The railway from Rémilly to Saarbrücken is a French and German 55-kilometre long railway line, that connects the French Grand Est region to the German city Saarbrücken. The railway was opened between 1851 and 1852. It is part of the international railway connection between Paris and Frankfurt am Main.

The railway from Strasbourg to Basel is a French and Swiss 141.3-kilometre long railway line. It is used for passenger and freight traffic. The railway was opened in 1840-1844.
The Strasbourg–Wörth railway is a French-German railway, which runs in the French region of Grand Est and the German state of Rhineland-Palatinate.

The Thionville–Trier railway connects Thionville in the French region of Grand Est with Trier in the German state of Rhineland-Palatinate. It also passes through the westernmost part of the Saarland along the Moselle for a few kilometres.