
The 1505 Lo Mustang earthquake occurred on 6 June 1505 and had an estimated magnitude between 8.2 and 8.8 making it one of the largest earthquakes in Nepalese history. The earthquake killed an approximate 30 percent of the Nepalese population at the time. The earthquake was located in northern Nepal, and affected southern China.

The 1995 India cyclone was a tropical cyclone that struck southeastern India which later spawned a rare snowstorm in Nepal, triggering the deadliest mountain trekking incident in the country's history in November 1995. The storm originated from the monsoon trough on November 7 in the Bay of Bengal, east of India, becoming the penultimate storm of the 1995 North Indian Ocean cyclone season. Moving northwestward, the system gradually intensified while moving toward land, eventually developing an eye in the middle of the convection. Reaching peak winds of at least 120 km/h (75 mph), the India Meteorological Department (IMD) classified the system as a very severe cyclonic storm on November 8, in line with intensity estimates from the American-based Joint Typhoon Warning Center (JTWC). On November 9, the cyclone made landfall near the border of Andhra Pradesh and Orissa. A typical for most November storms, the system continued to the north and dissipated over Nepal on November 11.

During the afternoon of 25 April 2015, a MW 7.8 earthquake struck Nepal and surrounding countries. Shaking from the quake triggered an avalanche from Pumori into Base Camp on Mount Everest. At least twenty-two people were killed, surpassing an avalanche that occurred in 2014 as the deadliest disaster on the mountain.

On 5 April 1970, during production of The Man Who Skied Down Everest, six Nepalese Sherpas died on Mount Everest. The deaths were caused by an ice-fall avalanche in the Khumbu Icefall. The icefall, which lies between Base Camp and Camp I, has been the site of numerous fatalities, including those in the 2014 Mount Everest ice avalanche. The Sherpas were assisting the Japanese Skiing Expedition, which included Yuichiro Miura, the first person to ski down Everest. Their names were Mima Norbu, Nima Dorje, Tshering Tarkey, Pasang, Kunga Norbu, and Kami Tshering. Another death occurred in the Japanese expedition four days later when Kyak Tsering was killed by ice falling from a serac.

The 1996 Mount Everest disaster occurred on 10–11 May 1996, when eight climbers caught in a blizzard died on Mount Everest while attempting to descend from the summit. Over the entire season, 12 people died trying to reach the summit, making it the deadliest season on Mount Everest at the time and the third deadliest after the 16 fatalities of the 2014 Mount Everest avalanche and the 22 resulting from avalanches caused by the April 2015 Nepal earthquake. The 1996 disaster received widespread publicity and raised questions about the commercialization of Everest.

On 18 April 2014, seracs on the western spur of Mount Everest failed, resulting in an ice avalanche that killed sixteen climbing Sherpas in the Khumbu Icefall. This was the same icefall where the 1970 Mount Everest disaster had taken place. Thirteen bodies were recovered within two days, while the remaining three were never recovered due to the great danger of performing such an expedition. Many Sherpas were angered by what they saw as the Nepalese government's meager offer of compensation to victims' families, and threatened a protest or strike. On 22 April, the Sherpas announced they would not work on Everest for the remainder of 2014 as a mark of respect for the victims.

The 2014 Nepal snowstorm disaster occurred in central Nepal during the month of October and resulted in the deaths of at least 43 people of various nationalities, including at least 21 trekkers. Injuries and fatalities resulted from unusually severe snowstorms and avalanches on and around the mountains of Annapurna and Dhaulagiri. The incident was said to be Nepal's worst trekking disaster.

On 2 August 2014, due to heavy rainfall, a landslide occurred at the Sunkoshi river, killing 156 people and blocking the river to form an artificial lake in Sindhupalchok District, Nepal. Araniko Highway, the main artery of goods and people flow to China, was blocked by the landslide ripping out 5 km of highway, and causing huge traffic jam. 2 dozens houses have been swept by the landslide. The landslide had a volume of 5.5 million cubic metres.

On 31 March 2019, a powerful "rainstorm" swept across two districts of southern Nepal killing at least 28 and injuring more than 1,100 people. It was later identified as the first confirmed case of a tornado in Nepal. Lacking advanced technologies to predict or record a tornado, the scientists instead based their findings on forensic evidence, including witness accounts. The government has insisted that technological upgrades are being instituted to improve the country's virtually non-existent weather-warning system.