
The regions of Djibouti are the primary geographical divisions through which Djibouti is administered.

Ali Sabieh Region is a region in southern Djibouti. With a mainland area of 2,400 square kilometres, it lies along the national border with Somalia and Ethiopia, bordering also the Dikhil Region to the west and the Arta Region to the north. Its capital is Ali Sabieh. The Arrei Mountains are the highest point in the region.

Arta Region is one of the six regions of Djibouti. It was officially created in 2003 by the regrouping of districts of the regions of Dikhil and Djibouti. It is situated in the south-central of the country, bordering the Tadjoura Region to the north, and the Djibouti Region to the north-east, and Dikhil Region the Ali Sabieh Region to the south, the country of Somalia lies to the east.

The Dikhil Region is a region in southern Djibouti. It is bordered by the Regions of Tadjoura to the north, Arta to the northeast, Ali Sabieh to the east. To the west and south, it has a long line with the Djibouti-Ethiopia border adjacent to the Ethiopia Regions of Afar Region and Somali Region. Dikhil Region is the largest Region in Djibouti by area, with a mainland area of 7,200 square kilometres, it is about the same size as Sikkim. The Dikhil Region's capital is the town of Dikhil.

Djibouti City is the eponymous capital and largest city of Djibouti. It is located in the coastal Djibouti Region on the Gulf of Tadjoura.

Djibouti Region, also known as the formerly Djibouti District is the capital of the Republic of Djibouti and one of the six regional administrative divisions of the country. With 603,000 residents across a total area of about 80 square miles, Djibouti Region is the most populous in Djibouti. It is the smallest region in Djibouti, and contains the national capital, Djibouti City.

Khor Angar is an administrative district in Djibouti.

The Obock Region is a region in northern Djibouti. It has a land area of 4,700 square kilometres, and had a population of 37,856 in 2009. It lies along the Red Sea, Bab-el-Mandeb, Gulf of Aden, Gulf of Tadjoura and includes the Seven Brothers, Doumeira Islands and the coastal city of Obock. It lies along a portion of the national border with Eritrea. In total area, it is larger than Cape Verde and smaller than Trinidad and Tobago. The topography of the region has highland and coastal plains.

The Tadjourah Region is a region in north-central Djibouti, the largest of its six regions. With its capital at Tadjourah, it has an area of 7,100 square kilometres. It lies along the Gulf of Tadjoura, Lake Ghoubbet and the coastal city of Tadjoura. The region has active salt and fisheries industries, and is served by the Tadjoura Airport. In total area, it is larger than Brunei and smaller than Cyprus.