
Abraham's Sacrifice of Isaac is a 1715 painting by the Baroque artist Federico Bencovich in the Strossmayer Gallery of Old Masters.

Bible Ki Kahaniyan is an Indian Hindi-language television program based upon scriptures from the Bible. The production aspired to complete both Old Testament and New Testament narratives of the Bible but was later discontinued after covering the Patriarch narrative in the Book of Genesis. It was produced by Appachan through his Navodaya Studio and was broadcast on DD National from 1992 to mid 1993 and again, concluding with the remaining episodes, in 1996.

The Binding of Isaac is a roguelike video game designed by independent developers Edmund McMillen and Florian Himsl. It was released in 2011 for Microsoft Windows, then ported to OS X, and Linux. The game's title and plot are inspired by the Biblical story of the Binding of Isaac. In the game, Isaac's mother receives a message from God demanding the life of her son as proof of her faith, and Isaac, fearing for his life, flees into the monster-filled basement of their home where he must fight to survive. Players control Isaac or one of seven other unlockable characters through a procedurally generated dungeon in a roguelike manner, fashioned after those of The Legend of Zelda, defeating monsters in real-time combat while collecting items and power-ups to defeat bosses and eventually Isaac's mother.

Gênesis is a Brazilian telenovela produced by RecordTV and Casablanca that premiered on 19 January 2021. The series is written by Camilo Pellegrini, Raphaela Castro, and Stephanie Ribeiro. It stars an ensemble cast featuring Zé Carlos Machado, Adriana Garambone, Oscar Magrini, Cássia Linhares, Miguel Coelho, Thaís Melchior, Pablo Morais, Francisca Queiroz, Juliano Laham, Letícia Almeida, Juliana Boller and Carlo Porto. The plot is based on the Book of Genesis.

In the Beginning is a 2000 American two-part biblical television miniseries directed by Kevin Connor. It stars Martin Landau and Jacqueline Bisset and originally aired on NBC on November 12 and 13, 2000.

Isaac Blessing Jacob is a 1642 religious painting by Gerbrand van den Eeckhout. It shows Jacob kneeling at the bed of his blind father Isaac under the watchful eye of his mother Rebecca as he receives his brother Esau's blessing. It is in the collection of the Metropolitan Museum of Art.

Jacob is a 1994 German/Italian/American television movie by Five Mile River Films, based on the novel Giacobbe by Francesco Maria Nappi, which is in turn based on a biblical account from the Book of Genesis about Jacob.

The Jewish Bride is a painting by Rembrandt, painted around 1665‒1669.

Rebekah (2001) is the second novel in the Women of Genesis series by Orson Scott Card.

The Sacrifice of Isaac is a 1635 autograph oil on canvas work by Rembrandt, now in the Hermitage Museum. A studio copy of it dating to 1636 is now in the Alte Pinakothek in Munich.

The Sacrifice of Isaac is the title of two paintings from c. 1598 - 1603 depicting the sacrifice of Isaac. The paintings could be painted by the Italian master Caravaggio (1571–1610) but there is also strong evidence that they may have been the work of Bartolomeo Cavarozzi, a talented early member of the Caravaggio following who is known to have been in Spain about 1617–1619.