
Abomination: The Nemesis Project, known in the United States as simply Abomination, is a real-time tactics/action video game released in 1999. In the game, the player leads a team of eight genetically altered supersoldiers (marines) to defeat an infestation of a global genetic plague which slowly turns into a superorganism.

Gunnm , also known as Battle Angel Alita in English, is a Japanese cyberpunk manga series created by Yukito Kishiro and originally published in Shueisha's Business Jump magazine from 1990 to 1995. The second of the comic's nine volumes was adapted in 1993 into a two-part anime original video animation titled Battle Angel for North American release by ADV Films and the UK and Australian release by Manga Entertainment. Manga Entertainment also dubbed Battle Angel Alita into English. A live-action film adaptation titled Alita: Battle Angel was released on February 14, 2019.

Michael Blumlein, M.D. was an American fiction writer and a physician. Blumlein attended medical school at the University of California, San Francisco and worked as a practicing doctor and member of the faculty at University of California, San Francisco for decades.

Crackdown is a series of action-adventure video games created by David Jones and published by Xbox Game Studios. The series takes place in a futuristic dystopian city controlled and enforced by a law enforcement organization called the Agency. The games center on the Agency's super soldiers, known as 'Agents', as they fight threats ranging from various criminal syndicates, a terrorist group known as 'Cell', and zombie-like monsters called 'Freaks'.

Crackdown 2 is an open world action-adventure video game developed by Ruffian Games and published by Microsoft Game Studios. It was released on Xbox 360 in July 2010 and is a direct sequel to the 2007 video game Crackdown. A sequel, Crackdown 3, was released for the Xbox One and Microsoft Windows in February 2019.

Cruelty Squad is a tactical first-person shooter developed by Finnish studio Consumer Softproducts and released in early access on Steam on 4 January 2021. In the game, the player takes on the role of a biologically-augmented assassin working for a subsidiary company tasked with performing black operations for its host conglomerate, and must kill various targets in order to progress. The game has been described by the developer as “an immersive power fantasy simulator with tactical stealth elements”. The game is notable for its bizarre and surreal aesthetic, which is inspired by the likes of Super Mario 64 and LSD: Dream Emulator.

DIYbio is an informal umbrella organization for individuals and local groups active in do-it-yourself biology, encompassing both a website and an email list. It serves as a network of individuals from around the globe that aims to help make biology a worthwhile pursuit for citizen scientists, biohackers, amateur biologists, and do-it-yourself biological engineers who value openness and safety. It was founded by Jason Bobe and Mackenzie Cowell in 2008.

Evolva is a third-person action game created by British computer artist William Latham and game designer/programmer Mark Atkinson, and released in 2000.

Final Fantasy VII Remake is a 2020 action role-playing game developed and published by Square Enix. It is the first in a planned series of games remaking the 1997 PlayStation game Final Fantasy VII. Set in the dystopian cyberpunk metropolis of Midgar, players control mercenary Cloud Strife. He joins AVALANCHE, an eco-terrorist group trying to stop the powerful megacorporation Shinra from using the planet's life essence as an energy source. The gameplay combines real-time action with strategic and role-playing elements.

Hackers is an anthology of science fiction short stories edited by Jack Dann and Gardner Dozois. It was first published in 1996. It contains stories by science fiction and cyberpunk writers of the late 1980s and early 1990s about hackers.

Gorky 17 is a turn-based tactics tactical role-playing game developed by Polish studio Metropolis Software and published by Monolith Productions for Microsoft Windows in 1999. The game was later ported to Linux by Hyperion Entertainment and published by Linux Game Publishing in 2006. The AmigaOS 4 version was released in 2015.

Gunman Chronicles or Half-Life: Gunman is a first-person shooter space western video game originally created as a mod by the now defunct Rewolf Software. Gunman Chronicles was originally a Quake deathmatch mod named Gunmanship 101, then it was moved to Quake II's engine before becoming a Half-Life mod. The game was popular at the Half-Life Mod Expo in 1999, and Sierra approached Rewolf to make a retail version. After significant work and with some office space, funding, and added staff, it was released as a standalone game. Plans were drawn to release Gunman Chronicles on GameCube, but it was never released.

GURPS Bio-Tech is a GURPS, the Generic Universal Role Playing Game, sourcebook that covers the implementation of biotechnology in the game. The first edition of the book was written for GURPS Third Edition, while the second edition of GURPS Bio-Tech was written for GURPS Fourth Edition. Both editions of the game are primarily focused on providing supplemental rules, campaign material, and examples of the uses of biotechnology for the players and game-master alike. The second edition contains two outlines for campaign settings but is primarily focused on providing rules and examples of devices that Game Masters could adapt for use in their own campaigns.

The terms human–animal hybrid and animal–human hybrid refer to an entity that incorporates elements from both humans and animals.
The Ooze is a video game developed by Sega Technical Institute and released in 1995 for the Sega Mega Drive/Genesis console. In the game, players take the role of a slimy puddle of liquid and face off against various enemies and obstacles.

Prototype is an open-world action-adventure video game developed by Radical Entertainment and published by Activision. The game was released in North America on June 9, 2009, in southwestern parts of North America as well as Oceania on June 10, and in Europe on June 12. Versions for PlayStation 4 and Xbox One were released on July 14, 2015 alongside the sequel as Prototype Biohazard Bundle. Separate versions of the games became available in August 2015.

Prototype 2 is a 2012 open world action-adventure video game. Developed by Canadian studio Radical Entertainment and published by Activision, it is the sequel to 2009's Prototype. The game was announced at the 2010 Spike VGA Awards. Versions for PlayStation 4 and Xbox One were released on July 14, 2015 alongside the first game as Prototype Biohazard Bundle. Separate versions of the games became available in August 2015.

Nanopunk refers to an emerging subgenre of science fiction that is still very much in its infancy in comparison to its ancestor-genre, cyberpunk, and some of its other derivatives.

Quake 4 is a military science fiction first-person shooter video game, the fourth title in the Quake series. The game was developed by Raven Software and published by Activision. Raven Software collaborated with id Software, the creators and developers of preceding Quake games. id Software supervised the development of the game as well as providing the id Tech 4 engine upon which it was built. Quake 4 went gold in early October 2005 and was released on October 18, 2005 for Microsoft Windows and later for Linux and OS X, as well as being a launch title for the Xbox 360. A special DVD Collectors Edition was released, including promotional material and the game Quake II with its expansions, The Reckoning and Ground Zero. The Xbox 360 version of Quake 4 is based on the Special Collectors Edition, and includes Quake II. On August 4, 2011, the game was made available through Steam.

Shadowrun is a science fantasy tabletop role-playing game set in a near-future fictional universe in which cybernetics, magic and fantasy creatures co-exist. It combines genres of cyberpunk, urban fantasy and crime, with occasional elements of conspiracy, horror and detective fiction. From its inception in 1989, Shadowrun has remained among the most popular role-playing games. It has spawned a vast franchise that includes a series of novels, a collectible card game, two miniature-based tabletop wargames, and multiple video games.

SiN is a first-person shooter video game developed by Ritual Entertainment and published by Activision in 1998. It uses a modified version of the Quake II engine. SiN is set in the dystopian future of 2037, where John Blade, a commander in a security force named HardCorps in the megacity of Freeport, is tasked to rid the city of a recreational drug that may be tied to the rival biotechnology megacorporation, SinTek.

SiN Episodes were a planned series of episodic games for Microsoft Windows that would have expanded upon the 1998 computer game SiN. A total of nine episodes were planned with only the first one released. Developed by Ritual Entertainment and powered by the Source game engine, the first episode "Emergence" was the first computer game by a major developer to both be produced episodically and delivered over the Internet without the intervention of a publisher. This was accomplished through Valve's Steam content delivery system.

SiN: Wages of Sin is an expansion pack for Ritual Entertainment's first-person shooter game SiN. Wages of Sin was developed by 2015 Games as their first retail product and published by Activision in 1999. Taking place after the events depicted in SiN, players once again assume the role of HARDCORPS officer John R. Blade as he attempts to stop Mafia boss Gianni Manero from taking control of the remnants of SinTEK following the disappearance of its villainous CEO, Elexis Sinclaire.

Transhuman Space (THS) is a role-playing game by David Pulver, published by Steve Jackson Games as part of the "Powered by GURPS" line. Set in the year 2100, humanity has begun to colonize the Solar System. The pursuit of transhumanism is now in full swing, as more and more people reach fully posthuman states.

Many of the tropes of science fiction can be viewed as similar to the goals of transhumanism. Science fiction literature contains many positive depictions of technologically enhanced human life, occasionally set in utopian societies. However, science fiction's depictions of technologically enhanced humans or other posthuman beings frequently come with a cautionary twist. The more pessimistic scenarios include many dystopian tales of human bioengineering gone wrong.

Vampire Hunter D is a series of Japanese novels written by Hideyuki Kikuchi and illustrated by Yoshitaka Amano since 1983.

Vivisector: Beast Within is a 2005 horror first-person shooter game released by 1C. The game is set in 1987 on a covert military installation on Soreo Island, where a riot has broken out by renegade geneticist Dr. Morhead's experimental human-animal hybrid soldiers. It is the player's job to help the General suppress the riot and regain control of the hybrid soldiers. The game features "vivisection point", which allows the player to remove an enemy's flesh when shot.