
Professor Cuthbert Calculus is a fictional character in The Adventures of Tintin, the comics series by Belgian cartoonist Hergé. He is Tintin's friend, an absent-minded professor and half-deaf physicist, who invents many sophisticated devices used in the series, such as a one-person shark-shaped submarine, the Moon rocket, and an ultrasound weapon. Calculus's deafness is a frequent source of humour, as he repeats back what he thinks he has heard, usually in the most unlikely words possible. He does not admit to being near-deaf and insists he is only a little hard of hearing in one ear.

Firefly is a fictional comic book character created by Harry Shorten and Bob Wood for MLJ Comics in 1940. He first appeared in Top-Notch Comics #8. Artist Warren King and writer Joe Blair loaned their talents to many of the Firefly's installments.

The Flash is a superhero appearing in a series of American comic books published by DC Comics. The character first appeared in Showcase #4, created by writer Robert Kanigher and penciler Carmine Infantino. Barry Allen is a reinvention of the original Flash, Jay Garrick.

The manga series Case Closed, known as Meitantei Conan in Japan, features a large number of recurring fictional characters originally created by Gosho Aoyama. The series takes place in modern-day Japan and follows amateur detective Jimmy Kudo who solves cases in an episodic fashion while in his childhood body and under the alias Conan Edogawa. He is joined by childhood friend Rachel Moore and her father Richard Moore who runs a detective agency. Throughout the series, Conan interacts and befriends many characters from various groups: the Tokyo Metropolitan Police, the local police in Conan's prefecture; The Junior Detective League, a group of children who solves mysteries for their clients and the FBI. He also befriends a few individuals who know of his true identity: Dr. Agasa, who provides Jimmy with various spy gadgets; Harley Hartwell, a high school detective from Osaka; and Anita Hailey, the original developer of the poison who had also transformed into a child.

Jonathan "Jack" Stanley Hodgins IV, Ph.D. is a character in the American television series, Bones. He is portrayed by T. J. Thyne. Hodgins is introduced to the series primarily as a forensic entomologist, as well as a botanist, mineralogist, a forensic palynologist, and a forensic chemist; conspiracy theories are his hobby. During an investigation, he is primarily responsible for estimating time of death and examining trace evidence and particulates.

Alec Holland is a fictional character in comic books published by DC Comics. He is most notably a character in the various Swamp Thing series.

Sherlock Holmes is a fictional detective created by British author Sir Arthur Conan Doyle. Referring to himself as a "consulting detective" in the stories, Holmes is known for his proficiency with observation, deduction, forensic science, and logical reasoning that borders on the fantastic, which he employs when investigating cases for a wide variety of clients, including Scotland Yard.

Honey Lemon is a fictional superhero appearing in American comic books published by Marvel Comics. The character is commonly associated with the Japanese team known as Big Hero 6. She was created by Steven T. Seagle and Duncan Rouleau, and first appeared in Sunfire & Big Hero 6 #1. She also appeared in the 2014 film adaptation of the comics.

Hourman or Hour-Man is the name of three different fictional superheroes appearing in comics published by DC Comics. The original Hourman was created by writer Ken Fitch and artist Bernard Baily in Adventure Comics #48, during the Golden Age of Comic Books. The first Hourman is chemist Rex Tyler, who creates a new synthesis, "Miraclo", which grants him super-strength and endurance, but only for one hour.

The Joker is a supervillain who appears in American comic books published by DC Comics. The Joker was created by Bill Finger, Bob Kane, and Jerry Robinson and first appeared in the debut issue of the comic book Batman on April 25, 1940. Credit for the Joker's creation is disputed; Kane and Robinson claimed responsibility for the Joker's design while acknowledging Finger's writing contribution. Although the Joker was planned to be killed off during his initial appearance, he was spared by editorial intervention, allowing the character to endure as the archenemy of the superhero Batman.

Roderick Kingsley is a fictional character, a supervillain appearing in American comic books published by Marvel Comics who appears as the first version of the Hobgoblin.

The Discworld is the fictional setting for all of Terry Pratchett's Discworld fantasy novels. It consists of a large disc resting on the backs of four huge elephants which are in turn standing on the back of an enormous turtle, named Great A'Tuin as it slowly swims through space. The Disc has been shown to be heavily influenced by magic and, while Pratchett has given it certain similarities to planet Earth, he has also created his own system of physics for it.

Alexander Joseph "Lex" Luthor is a fictional supervillain appearing in American comic books published by DC Comics. The character was created by Jerry Siegel and Joe Shuster. Lex Luthor originally appeared in Action Comics No. 23. He has since endured as the archenemy of Superman.

Angus "Mac" MacGyver is the title character and the protagonist in the TV series MacGyver. He is played by Richard Dean Anderson in the 1985 original series. Lucas Till portrays a younger version of MacGyver in the 2016 reboot.

Mister Hyde is a fictional character, a supervillain appearing in American comic books published by Marvel Comics. He is the father of Daisy Johnson.

The Molten Man is a fictional character appearing in American comic books published by Marvel Comics. Once a chemical engineer who longed to get rich, Mark Raxton was caught in an accident that saw his body get covered by an experimental organic-liquid metal alloy, which granted him superpowers, including the ability to generate extreme heat and radiation. Turning to a life of crime, he started off as an enemy of the superhero Spider-Man, but eventually was redeemed. He is also the stepbrother of Liz Allan.

Jack Napier, also known as the Joker, is a fictional character in the 1989 superhero film Batman, directed by Tim Burton. Portrayed by Jack Nicholson, the character was based on the iconic supervillain the Joker. His name is a play on the word Jackanapes, also a reference to the names Jack Nicholson and Alan Napier. This depiction is notable for being one of the first adaptations of the character to have a distinct first and last name, as well as one of the few instances that shows his origins. This iteration of the Joker is a psychopathic mobster who serves as the right-hand man of Gotham City crime boss Carl Grissom, until the latter attempts to have Napier killed.

Victoria October is a fictional character in the Batman comic books, created by writers James Tynion IV and Marguerite Bennett and by penciller and inker Ben Oliver. A transgender bioweapons expert and physician, she first appeared as an ally to Batman in March 2017 in Detective Comics, published by DC Comics. The character has generated positive critical commentary and academic interest.

The Big Four is a work of detective fiction by Agatha Christie, first published in the UK by William Collins & Sons on 27 January 1927 and in the US by Dodd, Mead and Company later in the same year. It features Hercule Poirot, Arthur Hastings, and Inspector Japp. The UK edition retailed at seven shillings and sixpence (7/6) and the US edition at $2.00.

Doctor Poison is the name of two fictional characters, supervillains who appear in DC Comics publications and related media. Both villains were members of the super-villain team Villainy Inc. and have appeared as major recurring enemies for Wonder Woman.

Professor Pyg is a supervillain who appears in comic books published by DC Comics. Pyg was created by Grant Morrison and Andy Kubert, and debuted as a corpse in the alternate reality story Batman #666 before being introduced as a recurring character in the mainstream DC Universe two years later in Batman and Robin #1. Professor Pyg was re-introduced following DC's The New 52 comics relaunch in 2011, appearing throughout the continuity and the subsequent DC Rebirth relaunch that began in 2016.

Dr. Henry Jonathan "Hank" Pym is a fictional character appearing in American comic books published by Marvel Comics. Created by penciler Jack Kirby, editor-plotter Stan Lee and scripter Larry Lieber, the character first appeared in Tales to Astonish #27. The character, a scientist that debuted in a standalone science-fiction anthology story, returned several issues later as the original iteration of the superhero Ant-Man with the power to shrink to the size of an insect. Alongside his crime-fighting partner-wife Janet van Dyne, he goes on to assume other superhero identities, including the size-changing Giant-Man and Goliath; the insect-themed Yellowjacket; and briefly the Wasp. He is a founding member of the superhero team the Avengers and the creator of the robotic villain Ultron.

Rebecca Chambers is a fictional character in the Resident Evil horror franchise by Capcom. She was introduced as a supporting character in the original Resident Evil video game in 1996 and became the protagonist of the prequel game Resident Evil Zero in 2002. In the first Resident Evil, Rebecca is a young officer with the Raccoon City Police Department’s Special Tactics And Rescue Service (S.T.A.R.S) unit and is trapped in a zombie-infested mansion. Zero depicts the events before that ordeal, during which she is separated from her team and forced to partner with escaped convict Billy Coen to survive similar circumstances.

Rikku is a fictional character in the Final Fantasy series. Tetsuya Nomura created Rikku, and the character is voiced by Marika Matsumoto in Japanese and by Tara Strong in English. Rikku first appears in Final Fantasy X as one of its protagonists, where she accompanies her cousin Yuna and others on a journey to defeat the monster Sin. Rikku again appears as a protagonist in the game’s direct sequel, Final Fantasy X-2. In that game, she, Yuna, and new friend Paine journey to find missing Final Fantasy X protagonist Tidus.

The Scarecrow is a fictional supervillain appearing in American comic books published by DC Comics. Created by Bill Finger and Bob Kane, he made his debut in World's Finest Comics #3. He is one of the most enduring enemies of the hero Batman and belongs to the collective of adversaries that make up the Dark Knight's rogues gallery.

Wendy Simms is a fictional character from the CBS crime drama CSI: Crime Scene Investigation, portrayed by Liz Vassey. She first appeared in the sixth season episode "Secrets and Flies", broadcast on November 3, 2005.

Severus Snape is a fictional character in J. K. Rowling's Harry Potter series. He is an exceptionally skilled wizard whose sarcastic, controlled exterior conceals deep emotions and anguish. A Professor at Hogwarts School of Witchcraft and Wizardry, Snape is hostile to Harry due to his resemblance to his father James Potter. According to the series, James bullied Snape during their time together at Hogwarts.

Trapster is a fictional supervillain appearing in American comic books published by Marvel Comics.

Walter Hartwell White Sr., also known by his alias Heisenberg, is a fictional character and the protagonist of the American crime drama television series Breaking Bad. He is portrayed by Bryan Cranston.