
Mega Man, known as Rockman in Japan, is the title character and the protagonist of the Mega Man series by Capcom. He was created by Akira Kitamura for the first Mega Man game released in 1987, with artist Keiji Inafune providing detailed character artwork based on Kitamura's pixel art design.

Mega Man X, known as Rockman X in Japan, with his name usually abbreviated to "X" , is the title character and main protagonist of Capcom's Mega Man X video game series originating in the 1993 Super NES video game Mega Man X. Mega Man X is an android who, along with his partner Zero, are elite members of the Maverick Hunters, a special police force tasked for defending humans and Reploids against criminal Reploids, known as Mavericks. Mega Man X has appeared in multiple printed adaptations of the series as well as an original video animation, Day of Sigma, which explores his early days as a hunter. Mega Man X is also a supporting character in the Mega Man Zero and Mega Man ZX video game series. Outside of the main Mega Man franchise, X has appeared in multiple crossover video games series.

Proto Man, known in Japan as Blues , is a fictional character from Capcom's Mega Man video game series. Proto Man first appeared in the 1990 video game Mega Man 3, and was known as Break Man. At the end of Mega Man 3, it is revealed that Break Man's actual name is Proto Man, and that he is Mega Man's older brother.

Roll is a fictional gynoid in the Mega Man video game series and its spin-offs. A housekeeper robot who acts as a little sister to Mega Man, she was built by the genius scientist Dr. Thomas Light, and parallels Astro Boy's Uran. Her name forms a "rock and roll" pun with Rockman, who is called Mega Man in Western territories.

Sigma is the main antagonist of the Mega Man X video game series. Created by Dr. Cain, Sigma was considered the finest of the Reploids and was the first leader of the Maverick Hunters, peacekeeping androids who defend humans against their renegade counterparts. Although he was once respectable, Sigma unexpectedly goes berserk during Mega Man X and rebels against humankind after coming into contact with the Maverick Virus. He defects to the Mavericks and assumes the role of their leader. Due to the virus integrated into his circuits, he can survive seemingly anything, and constantly returns to menace the world.

Doctor Albert W. Wily is a video game character and the main antagonist of the original Mega Man series, as well as Mega Man's archenemy. He appeared in the first Mega Man video game and later in promotions and other media related to the series. In Japanese, he is voiced by Takeshi Aono in all appearances except Mega Man: The Power Battle and its sequel, as well as Mega Man: Upon a Star, where he instead was voiced by Kenichi-Ogata; in English, the character is voiced by Douglas Kendall, Dean Galloway, Keith Silverstein, Ian James Corlett and Scott McNeil voicing the character in Mega Man 8, Mega Man Powered Up, Mega Man 11, Captain N: The Game Master, and the animated series, respectively.

Zero is a video game character present throughout Capcom's Mega Man franchise. Debuting in the Mega Man X series, Zero is an android and an elite Maverick Hunter: an organization dedicated to defending humanity from rogue Reploids, dubbed "Mavericks". Zero also acts as a mentor and longtime friend to X, the main protagonist of the X series. He continues his role as the titular main protagonist of the Mega Man Zero series. Zero has also played a supporting role in other series in the franchise such as the Mega Man ZX series and appeared in crossover video games as a guest character.